Nonspecific Interstitial Pneumonia (NSIP) Associated with Anti-KS Antibody: Differentiation from Idiopathic NSIP
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概要
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We report two cases of biopsy-proven nonspecific interstitial pneumonia (NSIP) with anti-KS (asparaginyl-tRNA) antibody. Anti-KS antibody is the sixth anti-aminoacyl-tRNA synthetase (ARS) antibody. They showed interstitial pneumonia without clinical symptoms, and high resolution computed tomography (HRCT) of the chest demonstrated consolidation along bronchovascular bundles and volume loss in the bilateral lower lobes, which were suggestive of connective tissue diseases (CTD). One case of cellular NSIP responded to corticosteroid, but the other case of fibrotic NSIP required corticosteroid and cyclosporin. In patients with these HRCT findings, the measurement of anti-ARS antibodies could be helpful even in the absence of clinical symptoms suggestive of CTD.
著者
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Okayasu Kaori
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Ohtani Yoshio
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Takemura Tamiko
Division of Pathology, Japan Red Cross Medical Center
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Uchibori Ken
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Tamaoka Meiyo
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Furuiye Masashi
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Miyazaki Yasunari
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Inase Naohiko
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Yoshizawa Yasuyuki
Department of Integrated Pulmonology, Tokyo Medical and Dental University
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Okayasu Kaori
東京医科歯科大学 呼吸器内科
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Ohtani Yoshio
Department Of Integrated Pulmonology Tokyo Medical And Dental University Tokyo Japan
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Furuiye Masashi
Department Of Integrated Pulmonology Graduate School Faculty Of Medicine Tokyo Medical And Dental Un
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Uchibori Ken
東京医科歯科大学 呼吸器内科
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Okayasu Kaori
Department Of Integrated Pulmonology Tokyo Medical And Dental University
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Miyazaki Yasunari
Department Of Integrated Pulmonology Tokyo Medical And Dental University
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Tamaoka Meiyo
Department Of Integrated Pulmonology Tokyo Medical And Dental University
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Inase Naohiko
Department Of Integrated Pulmonology Tokyo Medical And Dental University
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Yoshizawa Yasuyuki
Department Of Geriatric And Pulmonary Medicine Graduate School Tokyo Medical And Dental University
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Takemura Tamiko
Division of Pathology, Japan Red Cross Center
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