Analysis of Triglyceride Value in the Diagnosis and Treatment Response of Secondary Hemophagocytic Syndrome
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概要
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Background/Aims Secondary hemophagocytic syndrome (hemophagocytic lymphohistiocytosis, HLH) follows viral infection, malignant disorders, and autoimmune disease. Criteria for HLH diagnosis, which were proposed in 2004, include hypertriglyceridemia. However, some studies reported the absence of hypertriglyceridemia in patients with secondary HLH, differing from those with primary HLH. Subjects and Methods In this study, we investigated the presence or absence of hypertriglyceridemia in 28 patients who were diagnosed with secondary HLH between 1997 and 2007 retrospectively. There were no patients undergoing treatment for those with a history of hyperlipidemia. Results The subjects consisted of 14 patients with lymphoma-associated HLH, 11 with virus-associated HLH, 2 with autoimmune disease-associated HLH, and 1 with post transplantation HLH. In 19 patients (68%), hypertriglyceridemia was noted on diagnosis or during the disease period (mean: 242 mg/dL). Furthermore, the triglyceride (TG) level decreased with the treatment-related amelioration of HLH (mean level before and after treatment: 297 and 136 mg/dL, respectively, p=0.0001). Conclusion These results suggest that the TG level is useful for diagnosing HLH and evaluating the treatment response. TG measurement is simple and inexpensive; therefore, this parameter can be determined several times to evaluate the treatment response.
著者
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TAJIKA Kenji
Division of Hematology, Department of Internal Medicine, Nippon Medical School
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Dan Kazuo
Division Of Hematology Department Of Medicine Nippon Medical School
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Tajika Kenji
Division Of Hematology Department Of Internal Medicine Nippon Medical School
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Inokuchi Koiti
Division Of Hematology Department Of Internal Medicine Nippon Medical School
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Oshimi Kazuo
Department Of Hematology Juntendo University School Of Medicine
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Hamaguchi Hiroyuki
Department Of Hematology And Oncology Musashino Red Cross Hospital
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Gomi Seiji
Department Of Hematology Yokohama Minami Kyosai Hospital
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Okamoto Muneo
Division Of Hematology Department Of Medicine Nippon Medical School
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Yokose Norio
Department Of Internal Medicine Chiba Hokusoh Hospital Nippon Medical School
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Yamaguchi Hiroki
Division Of Hematology Department Of Internal Medicine Nippon Medical School
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Mizuki Taro
Division of Hematology, Department of Internal Medicine, Nippon Medical School
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Isobe Yasushi
Department of Hematology, Juntendo University School of Medicine
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