Additive Antihypertensive and Antihypertrophic Effects of Long-Acting Ca Blockers in Uncontrolled Hypertensive Patients With Angiotensin-Receptor Blocker Based Treatment
スポンサーリンク
概要
- 論文の詳細を見る
The aim of the present study was to examine the antihypertensive and antihypertrophic effects of combined treatment with a long-acting calcium antagonist on top of an angiotensin II receptor blocker (ARB) in uncontrolled hypertensive patients. Patients with essential hypertension and a blood pressure > 140/90 mmHg on ARB monotherapy (losartan 50 mg/day or candesartan 8 mg/day) were randomly assigned to a nifedipine controlled release (CR) group (n = 15) or amlodipine group (n = 11). A significant additional antihypertensive effect was noted from 1 month with nifedipine and 2 months with amlodipine. The average daily dose was 25 mg for nifedipine and 5 mg for amlodipine. The cardiothoracic ratio was significantly reduced in both groups after 3 months. Left ventricular wall thickness and left ventricular mass index also decreased. Metabolic parameters, hepatic function, and renal function did not change significantly. Additional treatment with a long-acting calcium antagonist achieved further blood pressure reduction as well as an antihypertrophic effect in the uncontrolled patients with prior ARB monotherapy.
- International Heart Journal刊行会の論文
著者
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Miyoshi Kei
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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Niimura Hideya
Department of Cardiology, Fukuoka University School of Medicine
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ANDO Chie
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
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Kodama Sunao
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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Urata Hidenori
Department Of Cardiology Fukuoka University School Medicine
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Inoue Yukiko
Department Of Biochemistry And Cellular Biology National Institute Of Neuroscience National Center O
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Okamura Keisuke
Department Of Cardiology Fukuoka University Hospital
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Mihara Hiroyuki
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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Tsuchiya Yoshihiro
Department Of Cardiology Fukuoka University School Of Medicine
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Yamanouchi Yoshio
Department Of 2nd Internal Medicine Fukuoka University
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Tsuchiya Yoshihiro
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
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Sumi Shunichiro
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
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Tojyo Hideaki
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
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Niimura Hideya
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
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Yamanouchi Yoshio
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
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