Sesaminol Glucosides Protect β-Amyloid Peptide-Induced Cognitive Deficits in Mice
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概要
- 論文の詳細を見る
This study was designed to investigate the effect of sesaminol glycosides (SG), one of the most abundant lignan glycosides in sesame (Sesamum indicum LINN.) seed, on cognitive deficits and oxidative stress induced by intracerebroventricular (i.c.v.) injection of β-amyloid protein (Aβ)25—35 in mice. Mice were fed diets containing 0%, 0.25%, or 0.5% of SG for six weeks. Dietary SG showed a protective effect against Aβ-induced learning and memory deficits in passive avoidance and the Morris water maze test. Aβ caused significant neuronal loss in the CA1 and CA3 regions of the hippocampus, but SG supplement showed decrease of the Aβ25—35 induced neuronal loss. The SG supplementation significantly decreased thiobarbituric acid reactive substance values and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in brain tissue. SG also reversed the activity of glutathione peroxidase (GPx), which is decreased by Aβ. These results suggest that SG protects against cognitive deficits induced by Aβ25—35, in part through its antioxidant activity.
- 日本薬学会の論文
著者
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KIM Mi
Department of Food and Nutrition, Chungnam National University
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Ahn Ji
Food Function Research Division Korea Food Research Institute
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Ha Tae
Food Function Research Division Korea Food Research Institute
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Um Min
Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans Unive
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Kim Suna
Food Function Research Group, Korea Food Research Institute
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Kim Mi
Department Of Anatomy School Of Medicine Kyungpook National University
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Kim Mi
Department Of Advanced Materials Science And Engineering Sungkyunkwan University
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Ahn Ji
Food Function Research Group, Korea Food Research Institute
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Kim Mi
Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University
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Um Min
Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University
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Ha Tae
Food Function Research Group, Korea Food Research Institute
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