Rapid-onset Primary Biliary Cirrhosis Resembling Drug-induced Liver Injury

元データ 社団法人 日本内科学会

概要

A 54-year-old woman was admitted to our hospital because of acute liver injury. Since she had a history of having used a diet product, drug-induced liver injury (DILI) was initially considered. However, the patient was subsequently diagnosed as suffering from primary biliary cirrhosis (PBC) based on the findings of liver histology and serum anti-mitochondrial antibody positivity. Overlap syndrome between PBC and autoimmune hepatitis (AIH) was also suspected, however, serum levels of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase became normal three months later, after treatment with combination therapy comprising ursodeoxycholic acid plus bezafibrate. We therefore concluded that the liver disease in this patient was actually PBC, but that it resembled overlap syndrome or DILI. In cases of PBC, a rapid onset, as frequently seen in the case of DILI, viral hepatitis or AIH, is not common. We herein report a rare case of PBC which resembled DILI.

著者

Sakisaka Shotaro Third Department Of Medicine Fukuoka University School Of Medicine
Shijo Hiroshi 福岡大学 医学部内科学第3
Shiga Hiroshi 福岡大学 医学部消化器内科学
SUZUKI Norihisa Third Department of Medicine, Fukuoka University School of Medicine
IWATA Kaoru Third Department of Medicine, Fukuoka University School of Medicine
IRIE Makoto Third Department of Medicine, Fukuoka University School of Medicine
ANAN Akira Third Department of Medicine, Fukuoka University School of Medicine
NAKANE Hidetoshi Third Department of Medicine, Fukuoka University School of Medicine
YOSHIKANE Makoto Third Department of Medicine, Fukuoka University School of Medicine
NISHIZAWA Shinya Third Department of Medicine, Fukuoka University School of Medicine
SOHDA Tetsuro Third Department of Medicine, Fukuoka University School of Medicine
WATANABE Hiroshi Third Department of Medicine, Fukuoka University School of Medicine
Suzuki Norihisa Third Department Of Medicine Fukuoka University School Of Medicine
Sohda Tetsuro Department Of Gastroenterology And Medicine Faculty Of Medicine Fukuoka University
Nakane Hidetoshi 福岡大学 医学部内科学第3
SHIGA Hiroshi Third Department of Medicine, Fukuoka University School of Medicine
Shijo Hiroshi Third Department Of Medicine Fukuoka University School Of Medicine
Shijo Hiroshi Frist Department Of Internal Medicine School Of Medicine Fukuoka University
Yoshikane Makoto Third Department Of Medicine Fukuoka University School Of Medicine
Shiga Hiroshi Third Department Of Medicine Fukuoka University School Of Medicine
Nishizawa Shinya Third Department Of Medicine Fukuoka University School Of Medicine
Sakisaka Shotaro Third Department Of Internal Medicine Fukuoka University
Nakane Hidetoshi Department Of Internal Medicine Fukuseikai Hospital

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