Heart Rate Variability and Hypercapnia in Duchenne Muscular Dystrophy
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概要
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Objective To investigate the relationship between heart rate variability and hypercapnia. Patients and Methods We measured the coefficient of variation of R-R interval (CVrr) and arterial blood gas pressures in 73 patients with Duchenne muscular dystrophy. Results CVrr was negatively correlated with arterial partial pressure of carbon dioxide (PaCO2). In patients whose CVrr was larger than 5%, 84% of them had no hypercapnia while the other 16% had hypercapnia (PaCO2 >45 mmHg). In contrast, 27% of those with CVrr smaller than 3% had no hypercapnia, 73% had hypercapnia and 47% had severe hypercapnia (PaCO2 >50 mmHg). Conclusion We first showed that CVrr was negatively correlated with PaCO2, and propose that abnormally low CVrr indicates respiratory insufficiency in patients with Duchenne muscular dystrophy.
- 社団法人 日本内科学会の論文
著者
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Shigeyama Toshiki
Department of Cardiology, Higashi-Saitama National Hospital
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Suzuki Mikiya
Department Of Neurology Sapporo Medical University School Of Medicine
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Ogata Katsuhisa
Department Of Neurology Graduate School Of Medicine The University Of Tokyo
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Tamura Takuhisa
Department Of Internal Medicine National Sanatorium Kawatana Hospital
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Miyatake Satoko
Department Of Human Genetics Nagasaki University School Of Medicine
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Ugawa Yoshikazu
Department Of Neurology Division Of Neuroscience Graduate School Of Medicine University Of Tokyo
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Kawai Mitsuru
Department of Neurology, Higashi-Saitama National Hospital
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MOCHIZUKI Hitoshi
Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University
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Okahashi Satomi
Department of Neurology, Higashi-Saitama National Hospital
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