Rebound Contraction by Nitric Oxide in the Longitudinal Muscle of Porcine Gastric Fundus

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概要

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• The rebound contraction induced by electrical field stimulation (EFS) and nitric oxide (NO) donor, S-nitroso-<sc>L</sc>-cysteine (cysNO), were investigated in the longitudinal muscle of porcine gastric fundus (LM-PGF). Under the presence of atropine and guanethidine, cysNO and EFS produced sequential relaxation-contraction in LM-PGF. Tetrodotoxin abolished the EFS-induced response, while leaving the cysNO-induced one unaffected. A soluble guanylate cyclase inhibitor, lH-[1,2,4]-oxadiazolo-[4,3-a]-quinoxalin-1-one, inhibited both cysNO and EFS-induced biphasic response. A cGMP analogue only relaxed LM-PGF. A phosphodiesterase V inhibitor, zaprinast, prolonged the cysNO and the EFS-induced relaxation and inhibited the rebound contraction. The rebound contraction was inhibited by verapamil, an L-type Ca2+ channel blocker. The cysNO and the EFS-induced biphasic response were inhibited by ryanodine plus cyclopiazonic acid or by ruthenium red, a ryanodine-receptor blocker. LM-PGF was relaxed on exposure to caffeine and then produced a verapamil-sensitive rebound contraction during the washout period. CysNO and EFS did not induce the rebound contraction in the presence of caffeine. These results suggest that the NO-induced rebound contraction involves both Ca2+-release from the ryanodine-sensitive store and Ca2+-influx through L-type channels. Although the NO-induced biphasic response is dependent on cGMP, rapid removal of cGMP seems necessary for the rebound contraction.

• 社団法人 日本薬理学会の論文
• 2002-08-01

著者

• Kim Taewan

  Samsung Advanced Institute of Technology, MD Lab

• Kim Taewan

  Department Of Veterinary Physiology College Of Veterinary Medicine Seoul National University

• Kim Taewan

  Department Of Physiology College Of Veterinary Medicine Kyungpook National University

• La Junho

  Department Of Veterinary Physiology College Of Veterinary Medicine Seoul National University

• YANG Ilsuk

  Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University

• SUNG Taesik

  Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University

• KANG Jeongwoo

  Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University

• SONG Hyunju

  Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University

• KIM Hyunju

  Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University

• Kim Hyunju

  Department Of Veterinary Physiology College Of Veterinary Medicine Seoul National University

• Yang Ilsuk

  Department Of Veterinary Physiology College Of Veterinary Medicine Seoul National University

• Sung Taesik

  Department Of Veterinary Physiology College Of Veterinary Medicine Seoul National University

• Song Hyunju

  Department Of Veterinary Physiology College Of Veterinary Medicine Seoul National University

• Kang Jeongwoo

  Department Of Veterinary Physiology College Of Veterinary Medicine Seoul National University

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• Rebound Contraction by Nitric Oxide in the Longitudinal Muscle of Porcine Gastric Fundus
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