Clinical Characteristics of Obesity-hypoventilation Syndrome in Japan: a Multi-center Study

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概要

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• Objective: To clarify the prevalence and clinical characteristics of obesity-hypoventilation syndrome (OHS) in a large number of patients with moderate to severe obstructive sleep apnea syndrome (OSAS). Methods: Subjects comprised 611 patients with OSAS registered from 7 sleep centers and clinics and analyzed according to the definitions of the Respiratory Failure Research Group of the Japanese Ministry of Health and Welfare. Baseline characteristics, polysomnographic data during sleep, laboratory blood examinations, excessive daytime sleepiness, pulmonary functions, and arterial blood gases were compared between OHS and non-OHS patients. Determinants of daytime hypercapnia were also examined in OHS patients. Results: OHS was identified in 55 of the 611 patients with OSAS (9%). OHS patients were younger, heavier, and more somnolent than non-OHS patients and displayed more severe OSAS, liver dysfunctions, higher total cholesterol, and impaired pulmonary function. However, these differences were resolved except for pulmonary function after correction for obesity. Daytime hypercapnia was associated with impaired pulmonary function. Percent vital capacity (%VC) was most closely correlated with PaCO2 in OHS. Conclusion: OHS patients display numerous abnormalities due to obesity compared with non-OHS patients. Impaired pulmonary function, particularly %VC, may play an important role in the development of daytime hypercapnia independent of obesity in OHS patients.

• 社団法人 日本内科学会の論文

著者

• NAKAMURA Hiroshi

  Nakamura Clinic

• Hida Wataru

  Health Administration Center Tohoku University

• Kawahara Seiji

  Respiratory Medicine Nihon University School Of Medicine

• Akashiba Tsuneto

  Respiratory Medicine Nihon University School Of Medicine

• AKAHOSHI Toshiki

  Respiratory Medicine, Nihon University School of Medicine

• Sakurai Shigeru

  Department Of Anatomy And Physical Anthropology Nihon University Graduate School Of Dentistry At Mat

• Chin Kazuo

  Respiratory Care And Sleep Control Medicine Graduate School Of Medicine Kyoto University Kyoto Japan

• SAKAKIBARA Hiroki

  Division od Respirology and Allergology, School of Medicine, Fujita Health University

• Uematsu Akihito

  Respiratory Medicine, Nihon University School of Medicine

• Katsura Kazuhito

  Respiratory Medicine, Nihon University School of Medicine

• Murata Akira

  Fourth Department of Internal Medicine, Nippon Medical School

• Sakakibara Hiroki

  Division of Respiratory, Medicine and Clinical Allergy, Fujita Health University School of Medicine

• Chin Kazuo

  Respiratory Medicine, Kyoto University School of Medicine

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