Factors Contributing to Sleep Disturbance and Hypnotic Drug Use in Hemodialysis Patients
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概要
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Objective: Sleep disturbance and the use of hypnotic medications are common in patients on hemodialysis. Factors that contribute to sleep disturbance and the use of hypnotic medications in hemodialysis patients were investigated. Methods: With the use of a questionnaire-based survey, we examined the prevalence of symptoms that reflect sleep disorders such as insomnia, restless legs syndrome (RLS), and snoring and use of hypnotic medications in 252 hemodialysis patients. Results: The overall prevalence of insomnia was 59.1%, with the prevalence of difficulty in initiating sleep (DIS), difficulty in maintaining sleep (DMS), and early morning awakening (EMA) being 47.6, 24.2, and 28.2%, respectively. Daytime sleepiness and habitual snoring were reported by 42.5 and 33.7%, respectively. The prevalence of routine use of hypnotic drugs was 25.8%. Both RLS and age were significantly associated with insomnia [odds ratio (OR), 3.75; p 0.001, OR, 1.03; p < 0.01]. RLS was a significant factor for DIS, DMS, and EMA (OR, 2.26; p < 0.05, OR, 3.44; p < 0.0005, OR, 4.25; p < 0.0005) and age was a significant factor for DMS and EMA (OR, 1.03; p = 0.053, OR, 1.05; p < 0.005). Both insomnia and snoring were associated with the use of hypnotic drugs (OR, 2.97; p < 0.001, 1.59; p=0.13). Conclusion: Both RLS and sleep-disordered breathing may contribute to sleep disturbance in hemodialysis patients. RLS in particular may be an important factor in insomnia, which in turn is likely responsible for the high prevalence of hypnotic drug use in hemodialysis patients.
著者
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Yasuma Fumihiko
Department Of Cardiology Nagoya University Graduate School Of Medicine
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NAKAI Shigeru
Department of Internal Medicine, Daiko Medical Center, Nagoya University School of Medicine
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Soga Taro
Department Of Psychiatry Nagoya University Graduate School Of Medicine
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Yokota Mitsuhiro
Department Clinical Laboratory Nagoya University Hospital
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MAEDA Kenji
Daiko Medical Center, Nagoya University
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Sugiura Tatsuki
Department Of Bioscience Graduate School Of Science And Technology Shizuoka University
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Ozaki Norio
Department Of Developmental Neurobiology Tohoku University Graduate School Of Medicine
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Iwayama Norihisa
Department of In-Home Medicine, Nagoya University Hospital
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Noda Akiko
the Nagoya University School of Health Sciences
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Atarashi Misaho
the Nagoya University School of Health Sciences
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Koike Yasuo
the Nagoya University School of Health Sciences
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Maeda Kenji
Daiko Sunadabashi Clinic
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Yasuma Fumihiko
Department of Cardilogy, Nagoya University, Graduate School of Medicine
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Sugiura Tatsuki
Department of In-Home Medicine, Nagoya University Hospital
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Soga Taro
Department of In-Home Medicine, Nagoya University Hospital
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