High dose Chemotherapy and Stem Cell Support in a Patient of Light- and Heavy-chain Deposition Disease with Abnormal Marrow Cell Surface Antigens and No Monoclonal protein

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概要

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• A 53-year-old man with nephrotic syndrome and severe renal failure was diagnosed with light- and heavy-chain deposition disease (LHCDD) by renal biopsy. The patient had no monoclonal protein and mild marrow plasmacytosis (6%), but marrow plasma cells expressed CD19-CD56+ and predominant monoclonal kappa-chain, indicating plasma cell dyscrasia. Conventional chemotherapy was ineffective and did not improve renal failure. High dose chemotherapy/peripheral blood stem cell transplantation (HDC/PBSCT) was introduced even after hemodialysis to eliminate aberrant clone and normalization of bone marrow cell surface markers. Immunophenotypic analysis of marrow cells facilitates clinical decision making regarding the use of HDC/PBSCT for LHCDD patients without monoclonal protein.

• 社団法人　日本内科学会の論文

著者

• OHNISHI Kazunori

  Third Department of Internal Medicine, Hamamatsu University School of Medicine

• HISHIDA Akira

  First Department of Medicine, Hamamatsu University School of Medicine

• Hishida Akira

  First Department Of Medicine Hamamatsu University School Of Medicine

• YONEMURA Katsuhiko

  Hemodialysis umit, Hamamatsu University School of Medicine

• Ohnishi Kazunori

  Third Department Of Internal Medicine Hamamatsu University School Of Medicine

• YAMAMOTO Tatsuo

  First Department of Medicine, Hamamatsu University School of Medicine

• FUJIGAKI Yoshihide

  First Department of Medicine, Hamamatsu University School of Medicine

• Yamamoto Tatsuo

  First Department Of Medicine Hamamatsu University School Of Medicine

• MIYAJI Takehiko

  First Department of Medicine, Hamamatsu University School of Medicine

• Tsuji Takayuki

  The First Department Of Medicine Hamamatsu University School Of Medicine

• SAKAKIMA Masanori

  First Department of Medicine, Hamamatsu University School of Medicine

• TSUJI Takayuki

  First Department of Medicine, Hamamatsu University School of Medicine

• FUKASAWA Hirotaka

  First Department of Medicine, Hamamatsu University School of Medicine

• NAITO Kensuke

  Third Department of Medicine, Hamamatsu University School of Medicine

• Fujigaki Yoshihide

  The First Department Of Medicine Hamamatsu University School Of Medicine

• Tsuji Takayuki

  First Department Of Medicine Hamamatsu University School Of Medicine

• Sakakima Masanori

  First Department Of Medicine Hamamatsu University School Of Medicine

• Fujigaki Yoshihide

  First Department Of Medicine Hamamatsu University School Of Medicine

• Yonemura Katsuhiko

  Hemodialysis Umit Hamamatsu University School Of Medicine

• 藤垣 嘉秀

  浜松医科大学第一内科

• YONEMURA Katsuhiko

  Hemodialysis Unit, Hamamatsu University School of Medicine

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