Azelnidipine Down-Regulates Renal Angiotensin-Converting Enzyme and Mineralocorticoid Receptor mRNA in Diabetic Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Effects of a new lipophilic L-type calcium channel blocker, azelnidipine, on the expression of molecular components of the renin-angiotensin-aldosterone system (RAAS) were assessed. Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of diabetes with hypertension, and their lean littermates, Long-Evans Tokushima Otsuka (LETO) rats, were treated with azelnidipine for 2 weeks. The renal cortical mineralocorticoid receptor mRNA in OLETF was higher than in LETO, but was suppressed (P<0.05) by azelnidipine. Renal cortical angiotensin-converting enzyme mRNA of OLETF was lower than that of LETO rats, and it was further suppressed by azelnidipine (P<0.05). Azelnidipine can down-regulate the gene expression of molecular components of RAAS.
- 公益社団法人 日本薬理学会の論文
著者
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Saito Yuichiro
Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine
-
Nakamura Tetsuya
Clinical Investigation And Research Unit Gunma University Hospital
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Kurabayashi Masahiko
Department Of Cardiology Kanazawa Medical University
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Saito Tomoko
Clinical Investigation And Research Unit Gunma University Hospital
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Saito Tomoko
Clinical Investigation and Research Unit, Gunma University Hospital, Japan
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Saito Yuichiro
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Japan
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