The Effects of HMG-CoA Reductase Inhibitor on Vascular Progenitor Cells
スポンサーリンク
概要
- 論文の詳細を見る
Circulating bone marrow-derived vascular progenitor cells contribute to angiogenesis, atherosclerosis, and the response to vascular injury. These vascular progenitor cells consist of two cell groups, endothelial progenitor cells (EPCs) and smooth muscle progenitor cells (SMPCs). Although HMG-CoA reductase inhibitors (statins) have been reported to inhibit atherosclerosis partially by increased EPCs, the effects of statins on SMPCs are unclear. Therefore, we investigated the relationship between EPCs and SMPCs and whether pravastatin has atheroprotective effects on SMPCs. Peripheral mononuclear cells (MNCs) were isolated and cultured on fibronectin-coated dishes in SMPC medium. MNCs were stained with acetylated low density lipoprotein and lectin, or α-smooth muscle actin, and cell numbers were counted. mRNA expression and vascular endothelial growth factor (VEGF) protein synthesis of MNCs were evaluated. Pravastatin significantly increased the number of EPC and decreased the number of SMPC. mRNA expression of VEGF, endothelial nitric oxide synthase, VEGF receptor-2 (KDR), and Akt were up-regulated, and VEGF secretion was increased by pravastatin. The present study demonstrated that pravastatin has promotive effects on the differentiation from MNCs to EPC cells, while inhibitory effects to SMPC cells. Our findings suggest a previously unreported mechanism of the effect of statin therapy on vascular progenitor cells.
- 公益社団法人 日本薬理学会の論文
著者
-
Matsumoto Ryo
Department Of Bioengineering Faculty Of Engineering Kagoshima University
-
Takeuchi Kazuhide
Department Of Internal Medicine And Cardiology Osaka City University Medical School
-
OMURA Takashi
Shirasagi Hospital
-
Yoshikawa Junichi
Osaka City University Graduate School Of Medicine
-
Enomoto Soichiro
Department Of Cardiology University Of Tokyo
-
Nishiya Daisuke
Department Of Cardiology Tsukazaki Memorial Hospital
-
Kusuyama Takanori
Department Of Cardiology Tsukazaki Hospital
-
Murata Takashi
Center For Diabetes National Hospital Organization Kyoto Medical Center
-
Yoshiyama Minoru
Department Of Cardiology And Internal Medicine Medical School Osaka City University
-
Yoshiyama Minoru
Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
-
Kusuyama Takanori
Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
-
Omura Takashi
Shirasagi Hospital, Japan
-
Takeuchi Kazuhide
Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
-
Murata Takashi
Center for Diabetes, National Hospital Organization Kyoto Medical Center, Japan
関連論文
- Effects of Gender on Prognosis of Patients With Known or Suspected Coronary Artery Disease Undergoing Contrast-Enhanced Dobutamine Stress Echocardiography
- Pocket-Sized Transthoracic Echocardiography Device for the Measurement of Cardiac Chamber Size and Function
- OJ-198 The Feasibility and Safety of Transnasal Transesophageal Echocardiography(OJ33,Echo/Doppler (New Technology) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Elevated Serum C-Reactive Protein Levels Predict Cardiovascular Events in the Japanese Coronary Artery Disease (JCAD) Study(Epidemiology)
- Impact of Electrocardiographic Left Ventricular Hypertrophy on the Occurrence of Cardiovascular Events in Elderly Hypertensive Patients : The Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS)
- PE-029 Influence of Coronary Plaque Characteristics in LMCA between Metabolic and Non-Metabolic Syndrome Subjects : A Volumetric IVUS Study(PE005,Metabolic Syndrome 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- Quantitative Analysis of Myocardial Contrast Enhancement by First-Pass 64-Multidetector Computed Tomography in Patients With Coronary Heart Disease(Imaging)
- Non-Invasive Assessment of Plaque Rupture by 64-Slice Multidetector Computed Tomography : Comparison With Intravascular Ultrasound
- PJ-231 Early and Subtle Neointimal Growth Detection Following Stent Implantation Using Intravascular Ultrasound and Optical Coherence Tomography and Histology(Intravascular endoscopy/Intravascular ultrasound-5 (I) PJ39,Poster Session (Japanese),The 70th A
- OE-067 Relationship Between Patterns of Calcification and Arterial Remodeling of Culprit Lesions, Comparing Acute Coronary Syndromes with Stable Angina(Acute Coronary Syndrome, Basic/Clinical 3 (IHD) : OE9)(Oral Presentation (English))
- Convalescent Stage Coronary Flow Reserve and Late Myocardial Morphologic Outcomes in Patients With First Anterior Acute Myocardial Infarction
- Slow-Flow Phenomenon during Percutaneous Coronary Intervention in Acute Myocardial Infarction : An Intravascular Ultrasound Study
- The Influences of Hemodialysis and AV-Shunt on Bilateral Internal Thoracic Artery Flows : An Ultrasound Study
- PE-112 Increased Plasma Oxidized LDL Levels are Associated with the Presence of Angiographically-detected Complex and Thrombotic Lesion Morphology in UAP Patients(Acute coronary syndrome, basic/clinical-5 (IHD) PE19,Poster Session (English),The 70th Anniv
- FRS-114 The Importance of Plaque Hemorrhage and Plaque Inflammation in the Destabilization of Human Carotid Atherosclerotic Plaques(Clinical Aspects of Atherosclerosis (H) FRS23,Featured Research Session (English),The 70th Anniversary Annual Scientific Me
- PE-557 Atrioventricular Delay Optimization under Echocardiographic Guidance in Patients with Normal Left Ventricular Systolic Function(PE093,Echo/Doppler (Others) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation
- PE-150 Prevalence of Left Atrial Thrombus in Atrial Fibrillation Patients with Anticoagulation Therapy(PE025,Thromboembolism/Antithrombotic Therapy/Thrombolysis 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulatio
- DPJ-030 Echocardiographic Assessment of Inefficient Left Ventricular Contraction in Patient Selection for Cardiac Resynchronization Therapy(DPJ05,Echo/Doppler (Myocardium) (I),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Jap
- OJ-196 Dobutamine-Induced Left Ventricular Mechanical Dyssynchrony : A Study Using Real-Time Three-Dimensional Echocardiography(OJ33,Echo/Doppler (New Technology) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulat
- FRS-112 Influence of the Early Ticlopidine Discontinuation on Clinical Outcomes following Sirolimmus-Eluting Stent Implantation(FRS23,Clinical Evidence of DES Era (1) (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japa
- FRS-111 Contemporary Practice Use of Sirolimus-Eluting Stents in Hemodialysis Patients : The Results from HIJ-DES Registry(FRS23,Clinical Evidence of DES Era (1) (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese
- 2 Prolonged Postischemic Regional Left Ventricular Delayed Relaxation or Diastolic Stunning in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Angioplasty(Frontiers in Diagnostic Echocardiography,Symposium 14 (SY-14) (M),The 73rd An
- 2 Prognostic Factors in Patients with Coronary Artery Disease Treated with Sirolimus-eluting Stent : The HIJ-DES registry(Current Status and Future Perspective of Drug-Eluting Stents,Plenary Session 1 (PL-1) (A),The 73rd Annual Scientific Meeting of The J
- Elevated E/E' Predicts Prognosis in Congestive Heart Failure Patients With Preserved Systolic Function(Heart Failure)
- Assessment of Aortic Atheromatous Plaque and Stiffness by 64-Slice Computed Tomography is Useful for Identifying Patients With Coronary Artery Disease
- PJ-201 Acute Hemodynamic Benefits of Biatrial Atrioventricular Sequential Pacing with the Optimal Atrioventricular Delay. : Comparison with Single Atrial Atrioventricular Sequential Pacing.(Arrhythmia, Non-Pharmacological Therapy 7 (A) : PJ34)(Poster Sess
- Progression of Post-Arteritis Lesions into Atherosclerotic Plaques in Kawasaki Disease(Congenital Heart Disease/Kawasaki's Disease 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-022 Feasible and Accurate Measurement of Left Ventricular Volume and Ejection Fraction by New Real-Time Three-Dimensional Echocardiography(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
- OJ-085 Simplified Three-dimensional Measurement of Left Ventricular Volume and Ejection Fraction Using Automated Contour Tracking Method(Echo/Doppler 1 (I) : OJ11)(Oral Presentation (Japanese))
- Coronary Flow Reserve Measurement Still Remains Useful in Diagnosing Coronary Stenosis Even in Patients with Coronary Risk Factors
- The Effect of Oral Glucose Loading on the Coronary Circulation in Healthy Young Adults : Analysis by Transthoracic Doppler Echocardiography
- Automated Quantification of Left Ventricular Function in Patients with Ischemic Heart Disease by Using Biplane Advanced Automated Contour Tracking Method
- PJ-819 The Usefullness of Hyperemic Trans-Stent Gradient for the Prediction of Restenosis following Sirolims-Eluting Stents Implantation(Coronary revascularization, PCI(26)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese C
- Peptide Mimics of Monocyte Chemoattractant Protein-1 (MCP-1) with an Antagonistic Activity
- Ig L-chain Shuffling for Affinity Maturation of Phage Library-derived Human Anti-human MCP-1 Antibody Blocking its Chemotactic Activity
- Structure-activity Relationship of Cytokine-mimic Peptide from Phage Library
- PJ-394 Beneficial Effects of Erythropoietin on Cardiac Remodeling after Myocardial Infarction(Growth factor/Cytokine-3 (H) PJ67,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Quantitative Assessment of Myocardial Perfusion by Intravenous Myocardial Contrast Echocardiography With Dobutamine Stress for Detection of Coronary Stenosis in Humans
- Physiologic Assessment of the Left Circumflex Coronary Artery Stenosis by Contrast- Enhanced Transthoracic Doppler Echocardiography : Comparison with Exercise 201-TI SPECT
- Value of diastolic reverse flow detection by contrast enhanced transthoracic Doppler echocardiography : Comparison with coronary angiography and exercise 201-TI scintigraphy
- Effect of black and green tea on coronary flow velocity reserve
- Noninvasive diagnosis of occluded left anterior descending coronary artery by diastolic reverse flow using transthoracic Doppler echocardiography
- Relationship Between Doppler-Derived Left Ventricular Diastolic Function and Exercise Capacity in Patients With Myocardial Infarction
- PJ-270 Microbubble Destruction with Ultrasound Augments Neovascularization by Bone Marrow Cell Transplantation in Rat Hindlimb Ischemia(Peripheral circulation-7 (H) PJ46,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- Effects of Cell Transplantation Using Vascular Endothelial Growth Factor-Expressing Mesenchymal Stem Cells for Myocardial Infarction(Acute Myocardial Infarction, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Beneficial Effect of Infarct-Related Artery Patency in Acute Anterior Myocardial Infarction in Patients With Poor Myocardial Viability in the Region-at-Risk
- The Long-Acting Ca^-Channel Blocker Azelnidipine Prevents Left Ventricular Remodeling After Myocardial Infarction
- Effects of Treatment for Diabetes Mellitus on Circulating Vascular Progenitor Cells
- The Effects of HMG-CoA Reductase Inhibitor on Vascular Progenitor Cells
- Effects of Erythropoietin on Cardiac Remodeling After Myocardial Infarction
- Granulocyte-Colony Stimulating Factor Augments Neovascularization Induced by Bone Marrow Transplantation in Rat Hindlimb Ischemia
- Angiotensin Blockade Inhibits Osteopontin Expression in Non-infarcted Myocardium After Myocardial Infarction
- HMG-CoA Reductase Inhibitor Increased Endothelial Progenitor Cells in Cultured Smooth Muscle Progenitor Cells (Lipid Disorders 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiogenic Progenitor Cells in Patients with Diabetes Mellitus (Diabetes/Obesity 7 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiotensin Blockades Inhibit Osteopontin Expression in Non-infarcted Myocardium after Myocardial Infarction(Old Myocardial Infarction/Remodeling 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Neutrophil Activation and Fibrin Formation in Intracoronary Thrombus Obtained from Patients with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Pathophysiology) 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
- Mid-band Lipoprotein Levels and Plasma Oxidized Low Density Lipoprotein Levels in Acute Myocardial Infarction versus Stable Angina Pectoris(Acute Coronary Syndrome, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Soc
- Effects of Eplerenone on Transcriptional Factors and mRNA Expression Related to Cardiac Remodeling after Myocardial Infarction(Renin-angiotensin-aldosterone System (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Cardioprotective Effect of SEA0400, a Selective Inhibitor of the Na^+/Ca^ Exchanger, on Myocardial Ischemia-Reperfusion Injury in Rats
- Effects of Cellular Cardiomyoplasty on Ventricular Remodeling Assessed by Doppler Echocardiography and Topographic Immunohistochemistry
- O-191 Facies differentiation of the Ordovician reefs in South China
- PE-195 Impact of Body Mass Index and Framingham Risk Score on Coronary Atherosclerotic Disease(Atherosclerosis, clinical-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Aldosterone Receptor Antagonist and Angiotensin II Type I Receptor Blocker on Cardiac Transcriptional Factors and mRNA Expression in Rats With Myocardial Infarction
- PJ-556 Effects of aldosterone antagonist and angiotensin II type I receptor blocker on cardiac AP-1 and NF-κB in myocardial infarcted rat(Old myocardial Infarction/Remodeling 2 (IHD) : PJ93)(Poster Session (Japanese))
- PJ-044 Cell Transplantation for the Treatment of Acute Myocardial Infarction Using Vascular Endothelial Growth Factor-Expressing Mesenchymal Stem Cells(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
- Granulocyte-Colony Stimulating Factor Augments Neovascularization Induced by Bone Marrow Transplantation in Rat Hind Limb Ischemia
- Immunohistochemical Characteristics of Aspirated IntracoronaryThrombi in Acute Myocardial Infarction
- Elevated levels of oxidized low density lipoprotein (ox-LDL) relate to plaque instability in diabetic patients
- Aspirated intracoronary thrombus by Rescue^ PT catheter : histological and immunohistochemical analyses
- Plasma oxidized low density lipoprotein levels in patients with coronary artery disease, gastritis with Helicobacter pylori infection, inflammatory bowel disease
- A link between high plasma oxidized low density lipoprotein (ox-LDL) levels and the severity of unstable angina pectoris
- Role of c-Jun NH_2 Terminal Kinase in G-Protein-Coupled Receptor Agonist-Induced Cardiac Plasminogen Activator Inhibitor-1 Gene Expression
- Involvement of c-Jun NH_2 Terminal Kinase and p38MAPK in Rapamycin-Mediated Inhibition of Neolntimal Formation in Balloon-Injured Rat Carotid Artery
- Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy through inhibition of AP-1 transcriptional activity
- Angiotensin II-induced cardiac MCP-1 gene expression is partially mediated by p38MAPK activation
- Endothelial progenitor cells prevent neointimal formation in balloon-injured rat carotid artery
- Nipradilol Can Prevent Left Ventricular Systolic and Diastolic Dysfunction After Myocardial Infarction in Rats
- Transmitral Inflow Pattern Assessed by Doppler Echocardiography in Angiotensin II Type 1A Receptor Knockout Mice With Myocardial Infarction
- Activation of Mitogen-Activated Protein Kinases in the Non-Ischemic Myocardium of an Acute Myocardial Infarction in Rats
- Observation of the Ischemic Cascade in Humans Using Contrast Echocardiography During Dobutamine Stress
- Transmural Distribution of Myocardial Perfusion Assessed by Intravenous Myocardial Contrast Echocardiography in Patients With Significant Left Anterior Descending Artery Stenosis
- Comparison of culprit lesions showing negative remodeling between acute coronary syndrome and stable angina pectoris
- Mechanism of Restenosis and Outcomes after Aggressive Coronary Stenting, Sized Using Intravascular Ultrasound
- Hepatocyte Growth Factor Production may be Related to the Inflammatory Response in Patients With Acute Myocardial Infarction
- Unruptured Aneurysm of the Sinus of Valsalva With Behcet's Disease
- Coronary Intimal Lesions in Patients with Kawasaki Disease Can Become Atherosclerotic Plaques Which May Cause Plaque Instability
- Sedimentary and biotic evidence of a warm-water enclave in the cooler oceans of the latest Ordovician glacial phase, Yangtze Platform, South China block
- OE-024 Neutrophil Infiltration and Activation in Aspirated Intracoronary Thrombi Obtained from Acute Myocardial Infarction Patients(Acute Myocardial Infarction, Clinical (Pathophysiology) 1 (IHD) : OE4)(Oral Presentation (English))
- Indirect Pulmonary Artery Pulse Diagnostic Significance in Transposition of Great Vessels
- Dating of Dissolved Iodine in Pore Waters from the Gas Hydrate Occurrence Offshore Shimokita Peninsula, Japan : ^I Results from the D/V Chikyu Shakedown Cruise
- PJ-386 Factors Related to Elevation of Circulating Oxidized Low Density Lipoprotein (Ox-LDL) Levels in Outpatients Without Coronary Artery Disease(Lipid Disorders 2 (IHD) : PJ65)(Poster Session (Japanese))
- Impact of Diabetes Mellitus on Worsening of the Left Ventricular Ejection Fraction in Exercise-Gated ^Tl Myocardial Single Photon Emission Computed Tomography in Patients With Coronary Artery Disease
- Multiple Risk Factors Relate to an Increase in Plasma Levels of Oxidized LDL in UAP Patients Aged under 50-Year-Old
- Effects of Smoking on Myocardial Injury in Patients With Conservatively Treated Acute Myocardial Infarction : A Study With Resting ^I-13-Iodophenyl 3-Methyl Pentadecanoic Acid/^Tl Myocardial Single Photon Emission Computed Tomography
- Positive Correlation between Oxidied Low Density Lipoprotein (Ox-LDL) Levels and Angiographic Morphology in Unstable Angina Pectoris (UAP)
- Cardioprotective Effect of SEA0400, a Selective Inhibitor of the Na+/Ca2+ Exchanger, on Myocardial Ischemia-Reperfusion Injury in Rats
- O-142 Ferruginous Carbonates and their relationship to the Frasnian-Fammenian boundary interval in Iran
- O-131 STRATIGRAPHY AND GEOCHEMISTRY OF FRASNIAN-FAMENNIAN BOUNDARY EVENT IN CENTRAL IRAN AND SOUTH CHINA
- The Effects of HMG-CoA Reductase Inhibitor on Vascular Progenitor Cells
- Peptide Mimics of Monocyte Chemoattractant Protein-1 (MCP-1) with an Antagonistic Activity.