Genetic Background in Patients with Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
The renin-angiotensin system is believed to play important roles in the development of acute myocardial infarction, and gene polymorphisms may also be involved. To investigate the genetic background in patients with acute myocardial infarction, we performed a case control study in a Japanese population. The study included 150 patients with acute myocardial infarction and 150 healthy, age- and sex-matched controls. We examined polymorphisms of angiotensin II type 1 receptor (1166 A / C), type 2 receptor (3123 C / A), and bradykinin B2 receptor (-58 T /C) in these subjects. The allelic frequencies of angiotensin II type 1 receptor C and angiotensin II type 2 receptor A were significantly higher in the acute myocardial infarction subjects than in the control subjects, and this tendency was more significant in the younger patients. The combined ratios of angiotensin II type 1 receptor C and type 2 receptor A alleles in patients under 64 years old were significantly higher than in their older counterparts. However the total numbers of conventional coronary risk factors (hypertension, hypercholesterolemia, diabetes mellitus, and smoking) in individual subjects were not significantly different between younger and older patients. These polymorphisms were found to be involved in the development of acute myocardial infarction, particularly in the younger patients, and it was concluded that the incidence of acute myocardial infarction might be reduced by management from the genotypes.
著者
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Itoh Seiji
Third Department Of Internal Medicine Showa University
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Sato Ryuji
Third Department Of Internal Medicine Showa University
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Aoki Shuichi
Third Department Of Internal Medicine Showa University
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Nishio Kazuaki
Third Department of Internal Medicine, Showa University School of Medicine
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Iwata Toshiki
Third Department Of Internal Medicine Showa University
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Mukae Shuji
Third Department Of Internal Medicine Showa University
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Katagiri Takashi
Third Department Inter Nat Medicine Showa University
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Ueda Hiroaki
Third Department Of Internal Medicine Showa University School Of Medicine
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ITOH Seiji
Third Department of Internal Medicine, Showa University School of Medicine
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MUKAE Shuji
Third Department of Internal Medicine, Showa University School of Medicine
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Aoki Shuichi
Third Department of Internal Medicine, Showa University School of Medicine
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Sato Ryuji
Third Department of Internal Medicine, Showa University School of Medicine
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