STUDY ON REPERFUSION INJURY ON SARCOPLASMIC RETICULUM IN ACUTE MYOCARDIAL ISCHEMIA
スポンサーリンク
概要
- 論文の詳細を見る
Reperfusion injury in early myocardial ischemia was studied in the dog with special reference to sarcoplasmic reticulum (SR) and contraction bands. Acute myocardial ischemia (1) was induced by occlusion of the left anterior descending coronary artery (LAD) for 10, 20 and 30 min followed by reperfusion for 15 min (R). Ca^>++<-ATPase activity of SR in 10-min-R-Group was significantly reduced to 60% of control activity, but activity of 10-min-I-Group remained near the control level in subendomyocardium (Endo). ATPase activity in 30-min-I-Group diminished to 60% of control activity in Endo and it was similar for 30-min-R-Group. In ischemic myocardium, composition of major ATPase protein decreased significantly in 30-min-I-Group and similar reduction was observed in 20-min-R-Group in Endo. In morphology proportion of appearance of contraction bands in Endo was significantly increased in 20-min or longer-R-Groups. These results suggest that reperfusion injury is likely to occur when coronary artery is reflowed after 10 min of ischemia. This may be caused by increased intracellular Ca^<++> at a very early stage of reperfusion period, and reperfusion injury may be induced due to acceleration in the necrotic process of the membrane system in the myocytes during ischemia.
- 社団法人日本循環器学会の論文
- 1992-04-20
著者
-
Itoh Seiji
Third Department of Internal Medicine, Showa University
-
KONNO Noburu
The Third Department of Internal Medicine, Showa University School of medicine
-
Mukae Syuji
Department Of Medicine Division Of Cardiology Showa University School Of Medicine
-
Itoh Seiji
Third Department Of Internal Medicine Showa University
-
Komo Noburu
The Third Department Of Internal Medicine School Of Medicine Showa University
-
Yanagishita Toshikuni
The Third Department of Internal Medicine
-
Mukae Syuji
The Third Department of Internal Medicine Showa University School of Medicine
-
Itoh Seiji
The Third Department of Internal Medicine, School of Medicine, Showa University
-
Ito Seiji
Third Department Of Internal Medicine Showa University
-
Shoji Makoto
Department Of Medicine Division Of Cardiology Showa University School Of Medicine
-
Yanagishita Toshikuni
The Third Department Of Internal Medicine School Of Medicine Showa University
-
Katagiri Takashi
The Third Department Of Internal Medicine Showa University
-
Yanagishita Toshikuni
昭和大学 第3内科
関連論文
- FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
- Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis
- High-Dose Granulocyte-Colony Stimulating Factor Promotes Neointimal Hyperplasia in the Early Phase and Inhibits Neointimal Hyperplasia in the Late Phase After Vascular Injury
- PE-150 Acceleration of vascular repair after injury in adiponectin-overexpressing mice.(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-809 ACE-Inhibitors and Angiotensin II Receptor Antagonists (ARB) Have Stronger Effects on Matrix Metalloproteinase Pathway and Anti-inflammation than Ca-antagonists(Hypertension, clinical-10, The 71st Annual Scientific Meeting of the Japanese Circulati
- FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
- PJ-809 ACE-Inhibitors and Angiotensin II Receptor Antagonists (ARB) Have Stronger Effects on Matrix Metalloproteinase Pathway and Anti-inflammation than Ca-antagonists(Hypertension, clinical-10, The 71st Annual Scientific Meeting of the Japanese Circulati
- PJ-809 ACE-Inhibitors and Angiotensin II Receptor Antagonists (ARB) Have Stronger Effects on Matrix Metalloproteinase Pathway and Anti-inflammation than Ca-antagonists(Hypertension, clinical-10, The 71st Annual Scientific Meeting of the Japanese Circulati
- PE-455 Increases in Serum Metalloproteinase-1, -13, and Interleukin-6 in the Culprit Coronary Artery in Patients with Acute Myocardial Infarction(Infection/Inflammation/Immunity-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-301 Low-density Lipoprotein (LDL)-cholesterol Levels Under Estimate Atherogenic LDL-cholesterol at Onset Acute Coronary Syndrome(Atherosclerosis, clinical-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-291 Significance of Small Dense LDL-Cholesterol, CRP, and Adiponectin as a Biomarkers to Predict Coronary Events in Stable Coronary Heart Disease(Atherosclerosis, clinical-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Production of hydrogen peroxide in situ in cardiac myocytes during hypoxia-reoxygenation as assessed with cerium
- The Involvement of TNF-α on Myocardial Remodeling after AMI through MMP Expression
- Bone Marrow Cells Differentiate into Neointimal Smooth Muscle Cells at the Injured Artery
- Matrix Metalloproteinases Are Involved in Pathogenesis of In-Stent Restenosis in Porcine
- The Expression of Stem Cell Marker in Neointima of In-Stent Resteonsis in Porcine Coronary Arteries
- Accumulation of Hematopoletic Cells Prior to Smooth Muscle Cells Hyperplasia
- Local delivery of a specific Rho-kinase inhibitor suppressed vascular remodeling after balloon angioplasty In porcine coronary arteries
- The Expression of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Pig Coronary Arteries following Coronary Intervention
- P636 ROLE OF ANGIOTENSIN II RECEPTOR ON VENTRICULAR REMODELING AFTER MYOCARDIAL INFARCTION
- OE-352 Adiponectin Transgenic Mice Prevents Neointimal Hyperplasia after Vascular Injury(Restenosis basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-307 Small Dense Low-Density Lipoprotein (LDL)-Cholesterol is a more Powerful Marker than LDL-Cholesterol in Determining Severe Coronary Atherosclerosis(Atherosclerosis, clinical-02, The 71st Annual Scientific Meeting of the Japanese Circulation Society
- OE-105 Suppression of TNF-alpha Improves the Recovery of Blood Perfusion in Hindlimb Ischemia Model(Growth factor/Cytokine-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-062 Role of Adiponectin in Vascular Injury Model Using Adiponectin Transgenic Mice(Atherosclerosis, basic-1 (H) OE11,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Postprandial Changes in LDL Phenotypes in Patients with Myocardial Infarction(Atherosclerosis, Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Close Linkage Between Hypoadiponectinemia and Small Dense LDL as a Potent Risk Factor for Coronary Heart Diseases(Preventive Medicine/Epidemiology/Education/Health Policy 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-164 Significance of Small Dense Low-density Lipoprotein-Cholesterol Concentrations in Relation to the Severity of Coronary Heart Diseases(Atherosclerosis, clinical-7 (H) PE28,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of th
- Significance of Small Dense Low-Density Lipoprotein-Cholesterol Concentrations as Angiographic and Clinical Severity of Coronary Heart Diseases (Atherosclerosis, Clinical 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-253 Smoking habits are associated with small dense LDL and high LDL-cholesterol in men with coronary heart diseases(Smoking 1 (H) : PE43)(Poster Session (English))
- OE-167 Eplerenone Suppressed Accumulation of Extra Cellular Matrix in Neointima After Coronary Stent Implantation in Swine(Restenosis after Angioplasty, Basic/Clinical 1 (IHD) : OE20)(Oral Presentation (English))
- Tumor-Necrosis-Factor-α-Gene-Deficient Mice Have Improved Cardiac Function Through Reduction of Intercellular Adhesion Molecule-1 in Myocardial Infarction
- Tumor Necrosis Factor-alpha Deficient Mice Decreased Expression of Intercellular Adhesion Molecule-1 After Myocardial Infarction
- Tumor Necrosis Factor-alpha Deficient Mice Improve Left Ventricular Function After Myocardial Infarction
- -0722- BENEFICIAL EFFECT OF PREINFERCTION ANGINA PECTORIS ON LEFT VENTRICULAR FUNCTION AFTER ACUTE MYOCARDIAL INFARCTION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- PE-068 Decreased expression of inflammatory mediators such as MMPs and ICAM-1 in AMI in TNF-α deficient mice(Acute Myocardial Infarction, Basic 3 (IHD) : PE12)(Poster Session (English))
- FRS-098 TNF-α Is Involved in Neointimal Formation after Vascular Injury Through Its Inflammatory Effects to Induce Bone Marrow Cells(Inflammation and Cardiovascular Disease (IHD) : FRS12)(Featured Research Session (English))
- FRS-061 A novel oral neutrophil elastase inhibitor, ONO-6818, suppressed early atherosclerotic plaque formation in apolipoprotein E-knockout mice(Oxidative Stress, Autonomic Function and Peripheral Vascular Diseases (H) : FRS7)(Featured Research Session (
- Improved Left Ventricular Function after Experimental Myocardial Infarction in Tumor Necrosis Factor-α (TNF-α) Deficient Mice
- Comparison between Self-Expanding and Balloon-Expandable Stents on the Mechanisms of In-Stent Restenosis in Porcine Coronary Arteries
- The Mechanism of In-Stent Restenosis in Radius Stent : An Experimental Porcine Study
- FRS-168 Bone marrow derived cells contribute to neointimal formation in porcine coronary arteries after stent implantation(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- 0906 EFFECTS OF ACE INHIBITOR ON Ca^-ATPase ACTIVITY OF SR AND ITS GENE EXPRESSION IN SHR HEARTS
- -0308- ENDOGENOUS CATALASE FILLS THE ROLE OF A CO-FACTOR WITH SUPEROXIDE DISMUTASE AS A DEFENSE MECHANISM AGAINST REPERFUSION INJURY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Contribution of monocyte chemoattractant protain-1 and macrophage-colony stimulating factor to coronary artery disease : Analysis of human coronary atherectomized tissues
- PJ-132 Development of New Catheter for Transendocardial Cell Transplantation into Heart(Regeneration (angionenesis/myocardial regeneration)-9 (M) PJ22,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-128 Improvement of Cardiac Function by Bone Marrow Stromal Cell Infusion from Cardiac Vein in Swine Myocardial Infarction Model(Regeneration (angionenesis/myocardial regeneration)-9 (M) PJ22,Poster Session (Japanese),The 70th Anniversary Annual Scienti
- PE-460 IL-6 May Develop Neointimal Hyperplasia through Its Inflammatory Effects(Growth factor/Cytokine-2 (H) PE77,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Parallel expressions of hepatocyte growth factor and matrix metalloproteinase-1 in balloon injured rat crotid artery
- Mitochondrial Respiratory Impairment in Streptozotocin-Induced Diabetic Rat Heart
- ALTERATIONS IN PHOSPHOLIPIDS AND COMPOSING FATTY ACIDS OF CARDIAC SARCOPLASMIC RETICULUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS : Pathophysiology : 53 Annual Scientific Meeting, Japanese Circulation Society
- OE-384 CRP and Interleukin-18 Polymorphisms Influence Serum Collagen and Inflammatory Markers, and Correlate with the Occurrence of Myocardial Infarction(Preventive medicine/Epidemiology/Education-1, The 71st Annual Scientific Meeting of the Japanese Circ
- OJ-080 ACE-Inhibitors (ACE-I) and Angiotensin II Receptor Antagonists (ARB) Have Potent Effects on Anti-inflammation(Hypertension, clinical-3 (H) OJ14,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- OE-140 CRP and Interleukin(IL)-18 Polymorphisms correlate with the Progression of Atherosclerosis and Occurrence of Myocardial Infarction(Preventive medicine/Epidemiology/Education-1 (H) OE24,Oral Presentation (English),The 70th Anniversary Annual Scienti
- 1076 EVALUATION OF SARCOPLASMIC RETICULUM Ca^-ATPase GENE IN NON-ISCHEMIC MYOCARDIUM OF INFARCTED MYOCARDIUM
- Generation of Free Radicals and the Damage Done to the Sarcoplasmic Reticulum During Reperfusion Injury Following Brief Ischemia in the Canine Heart
- Protective Effect of Captopril on Ischemic Myocardium
- THE EFFECTS OF SOD IN STUNNED MYOCARDIUM
- ANALYSIS OF HUMAN HEART FATTY ACID BINDING PROTEIN (h-FABP) IN EARLY STAGE OF ACUTE MYOCARDIAL INFARCTON
- ROLE OF OXIDATIVE STRESS ON REPERFUSIOIN INJURY : BIOCHEMICAL STUDY OF MICROORGANS
- ROLE OF MICROORGANS IN RECOVERY PROCESS OF MYOCARDIAL STUNNING
- METABOLIC IMPAIRMENT OF NON-INFARCTED MYOCARDIUM DURING PUMP FAILURE IN AMI : EFFECT OF AMRINONE ON MITOCHONDRIAL FUNCTION
- EFFECT OF PRECONDITIONING ON ISCHEMIC CELLULAR INJURY
- High Sensitivity C Reactive Protein(HSCRP) Activity and CRP Gene Polymorphisms were Associated with an Increased Risk of Hypertension(Infection/Inflammation/Immunity 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- ACE-Inhibitor and Antiotensin II Receptor Antagonists (ARB) Have Strong Anti-inflammatory Effects(Hypertension, Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- ACE-Inhibitor and Angiotensin II Receptor Antagonists (ARB) have a Stronger Effect on Cardiovascular Matrix Metalloproteinase Pathoway and Anti-inflammation than Ca-antagonists(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific
- C Reactive Protein (CRP) Genotype was Associated with Progression of Atherosclerosis and Occurrence of Myocardial Infarction(Cardiovascular Preventive Medicine (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- ALTERATION OF SARCOLEMMAL PERMEABILITY DUE TO ISCHEMIA AND REPERFUSION BY USE OF ELECTRON MICROSCOPY
- CLINICAL STUDIES ON THE CASES IN TOTAL CORONARY OCCLUSION WITH ABSENT Q-WAVE ON ECG : WITH EMPHASIS ON THE SIGNIFICANCE OF COLLATERAL VESSELS : Ischemic Heart Disease (VI) : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF T
- PE-331 Characterization of intermediate-sized LDLs associated with postprandial hyperlipemia in normotriglyceridemic patients with myocardial infarction(Atherosclerosis, Clinical 7 (IHD) : PE57)(Poster Session (English))
- DEGRADATION OF CARDIAC SARCOPLASMIC RETICULUM IN ACUTE MYOCARDIAL ISCHEMIA : Cardiac Metabolism (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- CHANGES IN CARDIAC SARCOPLASMIC RETICULUM IN THE ISCHEMIC MYOCARDIUM : A FREEZE-FRACTURE STUDY : Pathology, Morphology : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- COMPARATIVE STUDIES ON MORPHOMETRIC AND BIOCHEMICAL ANALYSIS OF MYOFIBRILS IN PATIENTS WITH CARDIOMYOPATHIES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiomyopathy
- ASSESSMENT OF PROTECTION OF ISCHEMIC MYOCARDIAL INJURY WITH BIOCHEMICAL AND ULTRASTRUCTURAL STUDIES IN CORONARY REPERFUSION MODEL EXPERIMENT : WITH EMPHASIS ON METHODOLOGY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOC
- Mitochondrial 5178A/C Genotype is Associated With Acute Myocardial Infarction
- The Genetic Factor in Acute Myocardial Infarction With Hypertension
- Promoter Polymorphism of the β_2 Bradykinin Receptor Gene is Associated With Essential Hypertension
- PE-599 Insulin Resistance as a Predictor for Restenosis after Coronary Stenting(Metabolism/Biochemistry/Energetics-2 (M) PE105,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- P776 STUDY OF HIGHLY SENSITIVE OXIMETRY FOR IN VIVO HEART TISSUES USING L-BAND ELECTRON SPIN RESONANCE
- OJ-328 ACE-Inhibitor and angiotensin II receptor antagonists (ARB) have stronger effects on matrix metalloproteinase pathway of collagen degradation compared to Ca-antagonists(Cardiovascular Pharmacology, Basic/Clinical 2 (H) : OJ39)(Oral Presentation (Ja
- OE-237 Bradykinin B2 receptor polymorphisms and promoter activity are associated with the occurrence of hypertension, myocardial infarction and ACE-inhibitor-related cough(Preventive Medicine/Epidemiology/Education 2 (H) : OE29)(Oral Presentation (English
- OE-027 Cyclin D1 870A/G genotype is associated with progression of atherosclerosis and occurrence of myocardial infarction(Acute Myocardial Infarction, Clinical (Pathophysiology) 1 (IHD) : OE4)(Oral Presentation (English))
- ACE-Inhibitor and Angiotensin II Receptor Antagonists Strongly Inhibit the Cardiovascular Remodeling
- Promoter Single Nucleotide Polymorphisms (SNPs) of ACE Gene Is Associated with Plasma ACE Activity
- Longevity-Related Mitochondrial 5178A/C Genotype Is Associated with the Effect of Medication for Hypertension
- Cyclin D1 Genotype Is Associated with Progression of Myocardial Infarction
- Association between Promoter Single Nucleotide Polymorphism (SNP) of Bradykinin B2 Receptor (BKR) and the Effect of Medication for Hypertension
- Promoter Single Nucleotide Polymorphisms (SNPs) of ACE Gene Have an Association with the Occurrence of Myocardial Infarction
- The Vitamin D receptor start codon polymorphism is associated with essential hypertension and longevity
- Promoter single nucleotide polymorphisms (SNPs) of ACE gene have a stronger association with myocardial infarction
- Evaluation of Mitochondria polymorphism as a risk factor for cardiac death in diabetic nephropathy with hemodialysis
- P331 CHANGE OF CARDIAC FUNCTION AND POLYMORPHISM OF ANGIOTENSIN CONVERTING ENZYME WITH ACUTE MYOCARDIAL INFARCTION
- IMPAIRMENT OF MITOCHONDRIAL RESPIRATORY ACTIVITY OF NON-INFARCTED MYOCARDIUM UNDER SEVERE PUMP FAILURE IN ACUTE MYOCARDIAL INFARCTION
- The effect of promoter single nucleotide polymorphism (SNP) of Bradykinin B2 receptor on cardiovascular diseases
- IMPAIRMENT OF SARCOLEMMAL PERMEABILITY IN THE ACUTE ISCHEMIC MYOCARDIUM : A Study with Ionic Lanthanum Probe Method
- STUDY ON REPERFUSION INJURY ON SARCOPLASMIC RETICULUM IN ACUTE MYOCARDIAL ISCHEMIA
- Degrading Process of Acute Ischemic Myocardial Cells : SYMPOSIUM ON PATHOPHYSIOLOGY IN THE EARLY STAGE OF ACUTE MYOCARDIAL INFARCTION AND ITS TREATMENT : 51th Annual Scientific Session of the Japanese Circulation Society
- IMPAIRMENT OF MITOCHONDRIAL RESPIRATORY ACTIVITY IN THE EARLY ISCHEMIC MYOCARDIUM : With Special Reference to Electron Transport System
- DEGRADATION OF THE CARDIAC SARCOPLASMIC RETICULUM IN ACUTE MYOCARDIAL ISCHEMIA
- ULTRASTRUCTURAL CHANGES IN THE SARCOPLASMIC RETICULUM IN ACUTE MYOCARDIAL ISCHEMIA
- G-CSF administered after reperfusion may improve cardiac function in swine AMI model(Apoptosis/Necrosis/Regeneration 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)