Continuous Administration of Nicorandil Decreases QT Dispersion During the Chronic Phase of Acute Myocardial Infarction
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概要
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We previously reported that continuous intravenous (IV) administration of nicorandil (NIC) inhibits QT dispersion (QTd). However, no prior study has evaluated the efficacy of NIC when administered orally to acute myocardial infarction (AMI) patients following continuous IV administration. Thirty patients with anteroseptal infarction in whom revascularization was performed successfully within 6 hours of AMI onset were included in the study and assigned to one of 3 groups: group A (continuous IV administration of NIC), group B (continuous IV and oral administration of NIC), and group C (no treatment with NIC). After 24 hours, QTd in groups A and B was significantly decreased compared to QTd in group C (P < 0.01) (group A, 58.1; group B, 58.2; and group C, 81.3). The QTd obtained 3 months later was significantly shorter in group B subjects who were orally administered NIC, and QTd before percutaneous coronary intervention (PCI) was restored in group A, in which no NIC had been administered orally [group A, 66.7; group B, 54.1; and group C, 73.9; P < 0.05 (group A versus group B) and P < 0.01 (group B versus group C)]. The effects were evaluated by comparing different routes of administration. Continuous IV and subsequent oral administration of NIC inhibited prolongation of QTd, suggesting that these effects may prevent the occurrence of cardiac events during both the acute and chronic phases of AMI.
- International Heart Journal刊行会の論文
著者
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Takahashi Nobuki
Deparment Of Medicine Division Of Cardiovascular Medicine Kurume University School Of Medicine
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Hiraoka Yuji
Department of Cardiology, Rakuwakai Otowa Hospital
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Yamazaki Taketoshi
Department of Cardiology, Rakuwakai Otowa Hospital
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Akagi Tadasu
Department of Cardiology, Rakuwakai Otowa Hospital
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Inai Yoshihito
Department Of Environmental Technology And Urban Planning Graduate School Of Engineering Nagoya Inst
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Hama Norio
Department Of Cardiology Rakuwakai Otowa Hospital
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Kitagawa Motoaki
Department Of Cardiology Rakuwakai Otowa Hospital
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Nakazawa Kiyoshi
Department Of Applied Physics Tokyo Institute Of Technology
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Matsumoto Naoki
Department of Anesthesia, Gunma Prefectural Cardiovascular Center
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Ueda Kinzo
Department of Cardiology, Rakuwakai Otowa Hospital
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Hamanaka Ichiro
Department of Cardiology, Rakuwakai Otowa Hospital
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Sarazawa Katsuhiro
Department of Cardiology, Rakuwakai Otowa Hospital
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Takebe Masato
Department of Cardiology, Rakuwakai Otowa Hospital
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Inai Yoshihito
Department of Cardiology, Rakuwakai Otowa Hospital
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Takahashi Nobuki
Department of Cardiology, Rakuwakai Otowa Hospital
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