Differential Cardiovascular Effects of Endotoxin Derived from Escherichia coli or Pseudomonas aeruginosa

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概要

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• Sepsis is characterized by various symptoms, signs and underlying pathophysiology. To investigate possible mechanisms underlying this diversity, we compared the cardiovascular effects of lipopolysaccharide (LPS) derived from Escherichia coli (E-LPS) with those of LPS from Pseudomonas aeruginosa (P-LPS) in rats. We also examined the possible roles of tumor necrosis factor-α (TNF-α) and oxidative stress in LPS-induced cardiovascular damage. E-LPS (10 mg/kg body weight) or P-LPS (2 mg/kg body weight) was administered intravenously to Wistar rats. Echocardiography was serially performed. E-LPS induced an increase in left ventricular fractional shortening that persisted for at least 6 h, whereas P-LPS elicited an initial increase and a subsequent decrease in this parameter. Histological analysis revealed that P-LPS induced interstitial edema, congestion, intramyocardial bleeding, myocardial necrosis, infiltration of inflammatory cells, and formation of fibrin thrombi in the heart, whereas no pathological changes were apparent in the hearts of rats treated with E-LPS. Furthermore, the plasma concentration of TNF-α in rats treated with P-LPS was greater than that in rats treated with E-LPS, but the glutathione redox ratio in the heart was not affected by either type of LPS. In conclusion, E-LPS and P-LPS induced distinct patterns of functional and structural responses in the cardiovascular systems of rats. These differential responses may be attributable in part to the difference in the associated increases in the plasma concentration of TNF-α. The cardiovascular effects of LPS thus depend on the causative organisms.

• Japanese Association for Laboratory Animal Scienceの論文

著者

• Nagata Kohzo

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• Kato Yosuke

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• IWASE Mitsunori

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• ICHIHARA Sahoko

  Department of Human Functional Genomics, Life Science Research Center, Mie University

• HASHIMOTO Katsunori

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• NODA Akiko

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• Ichihara Gaku

  Department Of Hygiene Nagoya University School Of Medicine

• Matsushita Aya

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• Ichihara Sahoko

  Department Of Biochemistry Vanderbilt University School Of Medicine

• Hashimoto Katsunori

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• Matsushita Aya

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• Iwase Mitsunori

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• Yokota Mitsuhiro

  Department Clinical Laboratory Nagoya University Hospital

• Hayashi Keiko

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• Koike Yasuo

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• Noda Akiko

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• KIMATA Hirotaka

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• YOKOI Toyoharu

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• HAYASHI Keiko

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• KATO Yosuke

  Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University

• YOKOTA Mitsuhiro

  Department of Genome Science, School of Dentistry, Aichi-Gakuin University

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