Effects of the White-Skinned Sweet Potato (Ipomoea batatas L.) on the Expression of Adipocytokine in Adipose Tissue of Genetic Type 2 Diabetic Mice

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概要

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• We investigated the effects of white-skinned sweet potato (WSSP) on the expression of adipose tissue adipocytokine in order to elucidate the mechanisms underlying the anti-diabetic effects of WSSP. A significant blood glucose lowering effect was observed starting 1 week after repeated administration of WSSP to KK-Ay mice. Expression of ACRP30, which is a homolog of adiponectin, was significantly higher in the WSSP-treated group than in the control group. Tumor necrosis factor-α expression indicated low tendency (p=0.09) in the WSSP treated group. The WSSP-treated group showed a greater tendency (p=0.09) than the control group for expression of the β-3-adrenoreceptor. These results suggest that one of the mechanisms of anti-diabetic action of WSSP is associated with improved action to the abnormal secretion of adipose tissue adipocytokines.

• 2005-12-01

著者

• NAKATSUGAWA SHIGEKAZU

  Department of Radiology, Nagoya University School of Medicine

• Tamasu Shogo

  Department Of Radiology Nagoya University Hospital

• Kusano Shuichi

  Research Institute Fuji Sangyo Co. Ltd.

• Nakatsugawa Shigekazu

  Department Of Radiology Nagoya University Hospital

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• The Effects of Static Magnetic Fields and X-rays on Instability of Microsatellite Repetitive Sequences
• Effects of the White-Skinned Sweet Potato (Ipomoea batatas L.) on the Expression of Adipocytokine in Adipose Tissue of Genetic Type 2 Diabetic Mice
• Isolation of Antidiabetic Components from White-Skinned Sweet Potato (Ipomoea batatas L.)
• Antidiabetic Activity of White Skinned Sweet Potato (Ipomoea batatas L.) in Obese Zucker Fatty Rats

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