The entire nucleotide sequence of baboon endogenous virus DNA : A chimeric genome structure of murine type C and simian type D retroviruses.
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概要
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We determined the complete nucleotide sequence of baboon endogenous virus (BaEV) strain M7. The total length of the retroviral DNA is 8, 507 base pairs. The order of viral proteins encoded is NH2-p12-p15-p30-p10-COON in the gag, NH2-protease-reverse transcriptase-endonuclease-COOH in the pol, and NH2-gp70-p20E-COON in the env genes. The transmembrane env protein, p20E, contains an amino acid sequence closely related to the "immunosuppressive peptide." Uncharacteristically, the pot and env genes do not overlap and are translated in the same frame. The deduced amino acid sequence of BaEV is related to 1) reticuloendotheliosis virus strain A in both the pol and env regions, 2) murine leukemia viruses in the pol but not in the env region, 3) simian type D retroviruses in the env but not in the pol region. This suggests that env genes in retroviruses may have been independently interchanged during evolution.
- 日本遺伝学会の論文
著者
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Takano Toshiya
Department Of Pathology Microbiology Keio University School Of Medicine
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Kato Shingo
Department Of Gastroenterology And Hepatology Saitama Medical Center Saitama Medical University
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Matsuo Koichi
Department Of Anesthesiology And Critical Care Medicine Jichi Medical University Saitama Medical Cen
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Takahashi Naomi
Department Of Bioscience Faculty Of Bioresources Mie University
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NISHIMURA Naoyuki
Grelan Pharmaceutical Co. Ltd.
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Takahashi Naomi
Department of Biological Chemistry and Food Science, Iwate University
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Kato Shingo
Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center
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TAKANO Toshiya
Department of Microbiology, Keio University School of Medicine
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MATSUO Koichi
Department of Microbiology, Keio University School of Medicine
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TAKAHASHI Naomi
Department of Microbiology, Keio University School of Medicine
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