ショウジョウバエRBP-Jκ遺伝子の成虫末梢神経系の発生におけるニュ-ロジェニックジ-ンとしての作用〔英文〕

スポンサーリンク

概要

• 論文の詳細を見る

• Drosophila RBP-Jκ is a novel sequence-specific DNA binding protein encompassing the integrase motif which is highly conserved in various organisms. Its gene has been shown to be identical to Suppressor of Hairless which regulates adult peripheral nervous system (PNS) development. To elucidate the precise function of the RBP-Jκ protein in adult PNS development, we analyzed transgenic flies that misexpress the RBP-Jκ protein. Such studies have shown that RBP-Jκ regulates PNS cell fate in at least two steps: commitment to sensory mother cell by lateral inhibition and terminal differentiation into the socket and shaft cells. Taken together with analysis of phenotypes of Suppressor of Hairless mutants, RBP-Jκ shows the synergistic activity with neurogenic genes.

• 日本遺伝学会の論文
• 1994-12-01

著者

• Honjo T

  Kyoto Univ. Kyoto Jpn

• Honjo Tasuku

  Department Of Immunology And Genomic Medicine Graduate School Of Medicine Kyoto University

• 古川 貴久

  Department of Medical Chemistry, Kyoto University Faculty of Medicine

• Honjo T

  Department Of Medical Chemistry Kyoto University Faculty Of Medicine

• Honjo Tasuku

  Department Of Medical Chemistry Graduate School Of Medicine Kyoto University Kyoto Japan

• Honjo T

  Department Of Medical Chemistry Faculty Of Medicine Kyoto University

• Honjo Tasuku

  Center For Molecular Biology And Genetics

• TAMURA Kumiko

  Department of Medical Chemistry, Kyoto University Faculty of Medicine

• Furukawa Takako

  Department Of Hygiene Kansai Medical University

• Tamura Kumiko

  Department Of Medical Chemistry Kyoto University Faculty Of Medicine

• Tanimura Teiichi

  Biological Laboratory, Kyushu University

• Tanimura Teiichi

  Biological Laboratory Kyushu University

• FURUKAWA Takahisa

  Department of Medical Chemistry, Kyoto University Faculty of Medicine

• KIMURA Kenichi

  Laboratory of Biology, Hokkaido University of Education

• KOBAYAKAWA Yoshitaka

  Biological Laboratory, Kyushu University

• KAWAICHI Masashi

  Department of Medical Chemistry, Kyoto University Faculty of Medicine

• Kawaichi M

  Nara Inst. Sci. And Technol. Nara Jpn

• Kobayakawa Yoshitaka

  Biological Laboratory Kyushu University

• Kimura K

  Laboratory Of Biology Hokkaido University Of Education

• HONJO Tasuku

  Department of Genetics, Osaka University Medical School

関連論文

• Identification of QTLs that modify peripheral neuropathy in NOD.H2^b-Pdcd1^ mice
• Requirement of lL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice
• Involvement of IL-10 in induction of autoimmune hemolytic anemia in anti-erythrocyte lg transgenic mice
• RBP-JxのショウジョウバエのホモログであるSuppressor of HairlessはE(spl)m8 neurogenic geneの転写を活性化する
• Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
• IS-KL2 Modulation of Immune Responses by PD-1, an Immuno-inhibitory receptor(Eosinophils, other Inflammatory Cells and Molecules in Allergy Keynote Lecture 2)
• Immunological studies on PD-1-deficient mice: implication of PD1 as a negative regulator for B cell responses
• Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
• Chromosomal mapping of two RBP-J-related genes : Kyo-T and RBP-L
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
• OJ-507 Autoantibodies against Cardiac Troponin I are the Critical Role for Autoimmune Dilated Cardiomyopathy(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese))
• Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4^- CD8^-) thymocytes
• PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
• Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice
• Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells : possible application to enhance T cell function
• Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID
• AID to overcome the limitations of genomic information by introducing somatic DNA alterations
• PD-1 and PD-1 ligands : from discovery to clinical application
• Suppressor of Hairless, the Drosophila homologue of RBP-Jκ, transactivates the neurogenic gene E(spl)m8
• Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice
• Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
• Female Myoblasts Can Participate in the Formation of a Male-specific Muscle in Drosophila
• Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells
• Studies on the Cell-Type Specific Expression of RBP-L, a RBP-J Family Member, by Replacement Insertion of β-Galactosidase
• ショウジョウバエRBP-Jκ遺伝子の成虫末梢神経系の発生におけるニュ-ロジェニックジ-ンとしての作用〔英文〕
• Author's reply : Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
• Type Two Hyper-IgM Syndrome caused by Mutation in Activation-Induced Cytidine Deaminase
• High frequency class switching of an IgM^+ B lymphoma clone CH12F3 to IgA^+ cells
• Loss of Immunostaining of the RBP-Jκ Transcription Factor upon F9 Cell Differentiation Induced by Retinoic Acid^1
• Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-typeHfh11 genomic locus
• Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity
• Interleukin 6 induces the hair follicle growth phase (anagen)
• PD-1 deficiency results in the development of fatal myocarditis in MRL mice
• Involement of Peripheral-Type Benzodiazepine Receptors in the Intracellular Transport of Heme and Porphyrins
• キイロショウジョウバエ自然集団における動く遺伝子P要素の多型〔英文〕
• Induction of Bip mRNA upon Programmed Cell Death of Differentiated PC12 Cells as Well as Rat Sympathetic Neurons^1
• Molecular basis of antibody memory(Mashimo Memorial Lecture,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Purification and Cloning of a Ribosomal RNA Gene Fragment from Mouse DNA
• Comparison of immunoglobulin .GAMMA.1 and .GAMMA.2b chain genes cloned from newborn mouse. Evolutional divergence of intervening sequences and structural basis for recognition of splicing sites.:Evolutional Divergence of Intervening Sequences and Structur

もっと見る 閉じる

スポンサーリンク