Synthesis and Antibacterial Activity of Quaternary Ammonium Salt-Type Antibacterial Agents with a Phosphate Group
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概要
- 論文の詳細を見る
Quaternary ammonium salts are frequently used as antibacterial agent that disrupts cell membrane through the binding of their ammonium cations to anionic sites in the outer layer tissue of bacteria. This article describes the synthesis of quaternary ammonium salt-type antibacterial agents with a phosphate group that strongly binds to hydroxyapatite and bromide ion as counterion. Evaluation of the antibacterial activity of the synthesized compounds in terms of minimum inhibitory concentration (MIC test) showed that the compounds exhibit an excellent antibacterial activity on a variety of bacteria including Gram-positive and Gram-negative bacteria, yeast, and fungi.
- 日本油化学会の論文
著者
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Yoshino Norio
Department Of Dental Radiology And Radiation Research Tokyo Medical And Dental University
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Kondo Yukishige
Department Of Industrial Chemistry Tokyo University Of Science
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Teranaka Toshio
Department Of Operative Dentistry And Endodontics Kanagawa Dental College
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Kawada Kazuo
Department of Chemistry, School of Science, Kitasato University
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Ohta Yumi
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science
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Teranaka Toshio
Department of Oral Medicine, Division of Restorative Dentistry, Kanagawa Dental College
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YOSHINO Norio
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science
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