Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats

スポンサーリンク

概要

• 論文の詳細を見る

• Metastin/kisspeptin, the KiSS-1 gene product, has been identified as an endogenous ligand of GPR54 that reportedly regulates GnRH/LH surges and estrous cyclicity in female rats. The aim of the present study was to determine if metastin/kisspeptin neurons are a target of estrogen positive feedback to induce GnRH/LH surges. We demonstrated that preoptic area (POA) infusion of the anti-rat metastin/kisspeptin monoclonal antibody blocked the estrogen-induced LH surge, indicating that endogenous metastin/kisspeptin released around the POA mediates the estrogen positive feedback effect on GnRH/LH release. Metastin/kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) may be responsible for mediating the feedback effect because the percentage of c-Fos-expressing KiSS-1 mRNA-positive cells to total KiSS-1 mRNA-positive cells was significantly higher in the afternoon than in the morning in the anteroventral periventricular nucleus (AVPV) of high estradiol (E2)-treated females. The percentage of c-Fos-expressing metastin/kisspeptin neurons was not different between the afternoon and morning in the arcuate nucleus (ARC). Most of the KiSS-1 mRNA expressing cells contain ERα immunoreactivity in the AVPV and ARC. In addition, AVPV KiSS-1 expressions were highest in the proestrous afternoon and lowest in the diestrus 1 in females and were increased by estrogen treatment in ovariectomized animals. On the other hand, the ARC KiSS-1 expressions were highest at diestrus 2 and lowest at proestrous afternoon and were increased by ovariectomy and decreased by high estrogen treatment. Males lacking the surge mode of GnRH/LH release showed no obvious cluster of metastin/kisspeptin-immunoreactive neurons in the AVPV when compared with high E2-treated females, which showed a much greater density of these neurons. Taken together, the present study demonstrates that the AVPV metastin/kisspeptin neurons are a target of estrogen positive feedback to induce GnRH/LH surges in female rats.

著者

• Maeda Kei-ichiro

  Laboratory Of Animal Reproduction Nagoya University School Of Agricultural Sciences

• Tsukamura Hiroko

  Laboratory Of Animal Reproduction Graduate School Of Bioagricultural Sciences Nagoya University

• Tsukamura Hiroko

  Laboratory Of Animal Reproduction Graduate School Of Agricultural Sciences Nagoya University

• UENOYAMA Yoshihisa

  Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University

• YAMADA Shunji

  Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University

• KINOSHITA Mika

  Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University

• Yamada Shunji

  Laboratory Of Animal Reproduction Graduate School Of Bioagricultural Sciences Nagoya University

• Adachi Sachika

  Graduate School of Science and Engineering, Saitama University

• Takatsu Yoshihiro

  Frontier Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd.

• MATSUI Hisanori

  Frontier Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd.

• TAKASE Kenji

  Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University

• SUGIURA Hitomi

  Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University

• OHTAKI Tetsuya

  Frontier Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd.

• MATSUMOTO Hirokazu

  Frontier Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd.

• INOUE Kinji

  Graduate School of Science and Engineering, Saitama University

• Maeda Kei-ichiro

  Laboratory Of Animal Reproduction Graduate School Of Agricultural Sciences Nagoya University

• Inoue Kinji

  Graduate School Of Science And Engineering Saitama University

• Agata Sachiko

  Graduate School Of Bioagricultural Sciences Nagoya University

• Sugiura Hitomi

  Laboratory Of Reproductive Science Graduate School Of Bioagricultural Sciences Nagoya University

• Matsumoto Hirokazu

  Frontier Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Co. Ltd.

• Adachi Sachika

  Graduate School Of Science And Engineering Saitama University

• Ohtaki Tetsuya

  Frontier Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Co. Ltd.

• Matsui Hisanori

  Frontier Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Co. Ltd.

• Maeda Kei-ichiro

  Laboratoey Of Animal Reproduction Graduate School Of Bioagricultural Sciences Nagoya University

• Kinoshita Mika

  Laboratory For Reproductive Science Graduate School Of Bioagricultural Sciences Nagoya University

• Yamada Shunji

  Laboratory For Reproductive Science Graduate School Of Bioagricultural Sciences Nagoya University

• Takatsu Yoshihiro

  Frontier Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Co. Ltd.

• Uenoyama Yoshihisa

  Laboratory for Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University

• MAEDA Kei-Ichiro

  Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University

• TSUKAMURA Hiroko

  Laboratory for Neural Architecture, Graduate School of Bioagricultural Sciences, Nagoya University

関連論文

• Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats
• Disruption in Ovarian Cyclicity Due to 2-Bromopropane in the Rat
• Expression of Porcine FSHβ Subunit Promoter-driven Herpes Simplex Virus Thymidine Kinase Gene in Transgenic Rats
• Acute Lipoprivation Suppresses Pulsatile Luteinizing Hormone Secretion without Affecting Food Intake in Female Rats
• Ovarian Toxicity of 2-Bromopropane in the Non-Pregnant Female Rat
• DISRUPTION OF DORSAL INPUT TO THE ANTERIOR HYPOTHALAMUS INDUCES LORDOSIS BEHAVIOR BUT NOT LUTEINIZING HORMONE(LH)SURGE IN ESTROGEN-TREATED CASTRATED MALE RATS
• THE BRAIN MECHANISM RESPONSIBLE FOR DASTING-INDUCED INHIBITION OF PULSATILE LUTEINIZING HORMONE (LH) SECRETION
• CENTRAL ADMINISTRATION OF MOTILIN SUPPRESSES PULSATILE LH RELEASE IN OVARIECTOMIZED RATS
• c -FOS EXPRESSION IN THE HYPOTHALAMUS AND MEDULLA OBLONGATA DURING FASTING IN MALE RATS WITH OR WITHOUT TESTOSTERONE TREARMENT
• DISTRIBUTION OF PANCREATIC GLUCOKINASE - LIKE IMMUNOREACTIVITY IN THE RAT LOWER BRAINSTEM
• MODULATING EFFECT OF ESTROGEN ON THE FEEDING BEHAVIOR INDUCED BY NORADRENALINE INJECTION INTO THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS IN OVARIECTOMIZED FEMALE RATS
• SUPPRESSIVE EFFECT OF THE ANTIMETABOLIC GLUCOSE ANALOG, 2 - DEOXY - D - GLUCOSE, ON PULSATILE LUTEINIZING HORMONE SECRETION IN OVARIECTOMIZED AND ESTRADOL - TREATED, OVARIECTOMIZED JAPANESE MACAQUE
• Estrogen Modulates Effects of Glutamate on In Vitro Gonadotropin-Releasing Hormone Release by Altering Nitric Oxide Action in Female Rats
• Paraventricular α1- and α2-Adrenergic Receptors Mediate Hindbrain Lipoprivation-induced Suppression of Luteinizing Hormone Pulses in Female Rats
• Neuroendocrine mechanism mediating energetic regulation of gonadotropin release in female rats
• A LONG-CHAIN FATTY ACID INDUCES INCREASE IN INTRACELLULAR CALCIUM CONCENTRATION IN THE PANCREATIC GLUCOKINASE-IMMUNOREACTIVE CELLS IN THE RAT MEDULLA OBLONAGATA
• GLUCOKINASE ACTIVITY IN EPENDYMOCYTES OF THE FOURTH VENTRICULAR IN FEMALE RATS
• THE EFFECT OF GLUCOSE INFUSION INTO THE DORSAL RAPHE NUCLEUS ON GLUCOPRIVIC SUPPRESSION OF PULSATILE SECRETION OF LUTEINIZING HORMONE IN THE RAT
• ROLE OF ATP AS A NEUROTRANSMITTER IN REGULATING REPRODUCTION IN THE BRAIN
• INVOLVEMENT OF GLUTAMATE AND NOREPINEPHRINE RELEASED IN THE ARCUATE NUCLEUS-MEDIAN EMINENCE REGION IN LUTEINIZING HORMONE SURGE INDUCED BY STEROIDS IN FEMALE RATS
• Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats
• Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats
• LOCALIZATION OF GALANIN-LIKE PEPTIDE (GALP) IN THE RAT BRAIN AND POSTERIOR PITUITARY GLAND
• Dose-dependent Effects of a Glucocorticoid on Prolactin Production
• GALP, a Novel Galanin-like Peptide Found in Porcine Hypothalamus : Isolation and cDNA Cloning
• アタキシン1をコードする脊髄性運動失調症原因遺伝子1(SCA1)が株化LH産生細胞LβT2に多く発現している
• Identification of Neuromedin U Receptors
• Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats
• ホルスタイン種雄牛の加齢にともなう血中ホルモン濃度の変化
• ウシ黄体細胞のプロスタグランジン産生におよぼす線維芽細胞成長因子の影響とその細胞内シグナル伝達経路
• Progesterone Stimulation by Prostaglandin F2α Involves the Protein Kinase C Pathway in Cultured Bovine Luteal Cells
• Age-Related Changes in the Serum Levels of Inhibin, FSH, LH and Testosterone in Holstein Bulls
• Basic Fibroblast Growth Factor-Induced Prostaglandin Production and Its Intracellular Mechanisms in Cultured Bovine Luteal Cells
• Prominent Expression of Spinocerebellar Ataxia Type-1 (SCA1) Gene Encoding Ataxin-1 in LH-Producing Cells, LβT2
• Expression of Porcine FSHβ Subunit Promoter-driven Herpes Simplex Virus Thymidine Kinase Gene in Transgenic Rats
• Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats
• Progesterone Stimulation by Prostaglandin F_ Involves the Protein Kinase C Pathway in Cultured Bovine Luteal Cells
• Secretion of Prostaglandins E_2 and F_ by the Bovine Endometrium in Response to Oxytocin during the Estrous Cycle
• 雌ラットにおけるアロキサン第4脳室内投与がパルス状黄体形成ホルモン分泌に及ぼす影響
• Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats
• Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats
• Synthesis and Biological Evaluation of a Novel Nonapeptide KISS1R Agonist with Testosterone-Suppressive Activity
• The effects of prolactin-releasing peptide (PrRP) in energy metabolism and stress
• Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats
• Estrogen Modulates Effects of Glutamate on In Vitro Gonadotropin-Releasing Hormone Release by Altering Nitric Oxide Action in Female Rats
• Immunocytochemical localization of kisspeptin neurons in the rat forebrain with special reference to sexual dimorphism and interaction with GnRH neurons
• Molecular Cloning and Identification of the Transcriptional Regulatory Domain of the Goat Neurokinin B Gene TAC3
• Dynorphin-Kappa Opioid Receptor Signaling Partly Mediates Estrogen Negative Feedback Effect on LH Pulses in Female Rats
• Dynorphin-Kappa Opioid Receptor Signaling Partly Mediates Estrogen Negative Feedback Effect on LH Pulses in Female Rats

もっと見る 閉じる

スポンサーリンク