Suppressive Effect of Astaxanthin Isolated from the Xanthophyllomyces dendrorhous Mutant on Ethanol-Induced Gastric Mucosal Injury in Rats
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概要
- 論文の詳細を見る
Ethanol has been found to induce ulcerative gastric lesion in humans. The present study investigated the in vivo protective effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant against ethanol-induced gastric mucosal injury in rats. The rats were treated with 80% ethanol for 3 d after pretreatment with two doses of astaxanthin (5 and 25 mg/kg of body weight respectively) for 3 d, while the control rats received only 80% ethanol for 3 d. The oral administration of astaxanthin (5 and 25 mg/kg of body weight) showed significant protection against ethanol-induced gastric lesion and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment with astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly indicated that the acute gastric mucosal lesion induced by ethanol nearly disappeared after pretreatment with astaxanthin.
- 社団法人 日本農芸化学会の論文
- 2005-07-23
著者
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Chang Hyo-ihl
Coll. Of Life Sciences And Biotechnology Korea Univ.
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Choi Seok-keun
Department Of Biotechnology School Of Life Sciences And Biotechnology Korea University
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KIM Jeong-Hwan
Department of Biotechnology, Yonsei University
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CHOI Sang-Yun
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University
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KIM Han-Kyeom
Department of Pathology, College of Medicine, Korea University Anam Hospital
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CHANG Hyo-Ihl
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University
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Chang Hyo-ihl
Department Of Biotechnology School Of Life Sciences And Biotechnology Korea University
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Kim Jeong-hwan
Department Of Biotechnology Yonsei University
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Kim Han-kyeom
Department Of Pathology College Of Medicine Korea University Anam Hospital
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Kim Jeong-hwan
Department Of Biology Jeju National University
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