Occurrence of a Tetrodotoxin-like Compound as a Minor Toxin in the Puffer Fish, Fugu flavidus
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概要
- 論文の詳細を見る
Toxins in ovaries and livers of the puffer fish, Fugu flavidus, were purified successively on activated charcoal, Bio-Gel P-2 and Bio-Rex 70. Besides tetrodotoxin (TTX), a minor toxin (toxin D) was newly detected in both tissues; toxin D accounted for 3% and 4% of the toll lethal potency in ovaries and livers, respectively. Although there were differences in the specific lethal activity, dose-survival time relation and signs in mice between toxin D and TTX, positive reactions to Weber reagent and 10% KOH, and a negative one to 1% H2O2 were observed for both toxins. Moreover, toxin D, like TTX, gave rise to the C9-base upon alkali-degradation. These results suggested that toxin D is a TTX-like compound having a quinazoline skeleton.
- 社団法人 日本農芸化学会の論文
著者
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NOGUCHI Tamao
Laboratory of Food Hygiene, Faculty of Fisheries, Nagasaki University
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Hashimoto Kanehisa
Laboratory Of Marine Biochemistry Faculty Of Agriculture The University Of Tokyo
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Shida Yasuo
Tokyo College Of Pharmacy
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YAMANAKA Hideaki
Laboratory of Food Hygienic Chemistry, Tokyo University of Fisheries
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HASHIMOTO Kanehisa
Laboratory of Marine Biochemistry, The University of Tokyo
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INAOKA Hakaru
Laboratory of Food Hygienic Chemistry, Tokyo University of Fisheries
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SHIOMI Kazuo
Laboratory of Food Hygienic Chemistry, Tokyo University of Fisheries
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KIKUCHI Takeaki
Laboratory of Food Hygienic Chemistry, Tokyo University of Fisheries
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