Structure-Activity Relationship and Design of an Antimutagen against the UV-Induced Mutation of Escherichia coli
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概要
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Structure-activity relationships of antimutagens were studied by assaying analogues and derivatives of 2(5H)furanone designed on the basis of the structures of natual antimutagens by the method of observing UV-induced reversion of E. coli WP2 B/r uvr A- trp E-. It is shown that an α, β-unsaturated carbonyl system is required for antimutagenic activity. Further modification of 3(2H)furanones resulted in the development of a highly potent antimutagen. The possibility that the antimutagenic effects may be due to alteration of proteins involved in the DNA repair system by trapping thiol groups is also discussed.
- 社団法人 日本農芸化学会の論文
著者
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KAKINUMA Katsumi
Laboratory of Chemisty, Faculty of Education, Yamagata University
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Ishibashi Keiji
Department Of Electrical Engineering Science University Of Tokyo
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Takei Hisashi
Department Of Life Chemistry Tokyo Institute Of Technology
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Takahashi Wataru
Department Of Cardiology National Hospital Organization Nagano Hospital
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KOIKE Junpei
Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology
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KAKINUMA Katsumi
Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology
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Ishibashi Keiji
Department of Life Chemistry, Tokyo Institute of Technology
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Takahashi Wataru
Department of Life Chemistry, Tokyo Institute of Technology
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