ラットがレバーを押し続ける行動にニコチンが及ぼす影響と衝動性について

概要

論文の詳細を見る
Impulsivity, the tendency to act without foresight, is a characteristic of behavior that can being seen in everyday life, but high level of impulsivity is associated with a number of psychiatric disorders including attention deficit hyperactivity disorder (ADHD) and drug addiction. It has been suggested that impulsivity is not a unitary construct, but rather a multi-faceted　construct. This study take up the behavioral paradigm that rats were required to keep pressing a lever to assess these impulsive behavior. In this paradigm, rats were required to keep pressing a lever for 4 seconds to obtain electrical stimulation of medial forebrain bundle, and to release the lever to begin next trial once they obtained electrical stimulation. Nicotine (0.4mg/kg, s.c.), suggested to increase impulsivity, had no effect on the percentage of responses to keep pressing the lever for 4 seconds, but decreased response latencies, and accelerated to release the lever after they had obtained a electrical stimulation. These results suggested that nicotine decreased impulsive behavior, specially to stop responses occur.
2011-03-15