膀胱癌患者の細胞性免疫能に関する研究第7報 : 患者血中β2-Microglobulin(β2-MG)について

概要

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Various immunological inhibitory factors were found in patients with malignant diseases. The β2-microglobulin (Β2-MG) was synthesized by many kinds of nuclear cells and malignant human cells; and, this protein had a structual relationship to immunoglobulins and HLA antigen. In the present study, we measured the serum β2-MG of 12 control subjects and 45 patients with urinary bladder carcinoma having normal renal function by radioimmunoassay. The serum β2-MG concentration was elevated in high grade and high stage patients. But the difference was not significant between control subjects and low grade or low stage patients. The level of β2-MG was markedly decreased after operation in high grade and high stage groups. There was a correlation between β2-MG concentration and phytohemagglutinin-induced lymphocyte blastogenesis in the patients. It is suggested that Β2-MG might be effective in augmenting the cellular immune response in patients with urinary bladder carcinoma.
泌尿器科紀要刊行会の論文