Piperacillin(T-1220)の泌尿***緑膿菌感染症に対する臨床的検討

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T-1220, a new broad antibacterial penicillin, was administered to patients with infections of urinary tracts and male genital organs caused by Pseudomonas sp., and the following results were obtained. 1) Minimal inhibitory concentrations of T-1220, CBPC, SBPC, GM and DKB were determined on 23 strains of Pseudomonas sp. isolated clinically. Antibacterial activity of T-1220 was higher than that of CBPC and SBPC. GM and DKB had superior activity to T-1220, but a few strains were resistant to GM and DKB. 2) 11 patients with complicated urinary tract infections caused by Pseudomonas sp. were treated at a daily dose of 4-6 g of T-1220 for 7-17 days. The therapeutic results were excellent in 4 cases, good in 6 cases and poor in 1 case, and the effective rate of these was 90.9%. 3) The significant relationship between clinical result and MIC was not observed, but there was a difference between the indwelling catheter group and the non-indwelling group and the excellent effectiveness was observed in the non-indwelling catheter group more than in the indwelling group. 4) In one case out of II cases, the elevation of GOT, GPT and alkaline phosphatase was observed.
泌尿器科紀要刊行会の論文