前立腺肥大症に対するPolyene Macrolide投与の影響

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Amphotericin B, one of the polyene macrolide preparations, was administered to 10 cases of prostatic hypertrophy associated with hypertension, cardiac insufficiency or diabetes mellitus in a daily dose of 800~ 1,200 mg for a period of 2~ 10 weeks. All of these cases were on conservative therapy. The object of the administration was to study the effect of amphotericin B with respect to the reduction of adenoma, improvement of clinical symptoms as well as laboratory results. As a result of the administration, marked reduction of adenoma was observed in one case, moderate reduction in 5 and 3 showed little change in adenoma. Improvement of dysuria and frequency at night was noted in 7 cases, whereas 3 showed little change in the symptoms. Disappearance of residual urine was observed in 4, reduction in 3, and the remaining 3 showed little change in the symptoms. It can be said, consequently, that the administration of amphotericin B produced marked effect in one, effect in 5, moderate effect in one and poor effect in 3. One of 5 cases showing effect was prostatectomied thereafter for histological examination which revealed the sloughing of the glandular epithelium, dilated glandular lumen and granulation-like changes. Atrophy of the glandular structure was not observed.
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