FT-207と5-FUの経膀胱的吸収に関する比較 --雑種成犬を用いた基礎的検討--

概要

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雑種成犬10匹を2群に分け,FT-207あるいは5-FUをそれぞれ1,200 mg膀胱内に注入した.FT-207, 5-FUともに血中に吸収され,その上FT-207の吸収率は5-FUの約40倍高かった.両薬剤とも血中によく吸収されたのは分子量が小さいことによるもので,両薬剤の吸収率の差はpH 6～7における非イオン型分子の存在率の差,つまりイオン化定数pkaの差によることがわかったFT-207 and 5-FU (1,200 mg) were administered intravesically to 5 mongrel dogs, and their concentration in the serum and bladder wall was measured. The serum concentration was high in both groups because their molecular weights are less than 200. The serum concentration of FT-207 was approximately 40 times higher than that of 5-FU. This difference may be due to the fact that non-ionized molecules in FT-207 account for more than 80% but those in 5-FU account for less than 10%.