男性不妊症に対する牛車腎気丸の効果

概要

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本剤は八味地黄丸にゴシツ,シャゼンシを加味した漢方薬である.その粉末5.0 g/日を男性不妊症患者中,無力精子症3例,乏精子症27例の計30症例に3ヵ月以上投与し,検討した.1)精子運動率に対して53%の症例に有効性を認めた.2)精子数は33%に有効な増加を認め,ことに精子濃度10×106/ml以上の症例に有効であった.3)妊娠成立は30例中1症例のみであった.4)血清LH, FSH,及び精液中prostaglandin E値には本剤投与前後において有意の変動は認められなかったNo study has been reported of the effects of Goshajinkigan on male infertility. Thirty infertile male patients were orally given Goshajinkigan at a daily dose of 5.0 g for three months or more. Sixteen of these patients showed significant improvement in sperm motility. Ten cases showed effective increase in sperm count. Only one patients became pregnant during the period of administration of this drug. Laboratory examination showed no significant change in serum LH, serum FSH or prostaglandin E in seminal fluid. These results suggest that administration of TSUMURA-Goshajinkigan is effective as therapy for male infertility, but how this drug may be involved in promoting fertility should be investigated in future.