エタノール加ペプロマイシン灌流による膀胱癌温熱療法

概要

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10例の膀胱癌症例に対し,エタノール加ペプロマイシン灌流による膀胱癌温熱療法を施行し,うち6例に25%以上の腫瘍縮小効果が認められた.しかし腫瘍の完全消失例が認められなかったことにより,本療法による根治性は否定的と考えられたDistilled water containing 40 micrograms/ml peplomycin and 2% ethanol was used as a perfusate in 8 patients with superficial bladder tumors and 2 with deep bladder tumors for 2 hours at 43 degrees C. In addition, immediately before the perfusion treatment, 5 mg of peplomycin was injected intramuscularly. Prior to treatment, the nature and extent of the tumors were determined by ultrasonography, cystoscopy and cystography. The therapeutic effect of the hyperthermic perfusion was evaluated by the same manner as used previously. Partial tumor regression was obtained in 6 of the 8 patients with superficial bladder tumors. The 2 patients with deep bladder tumors showed no tumor regression. Most of the patients had bladder discomfort such as irritation, pollakisuria and so on, during and/or after perfusion. No patient developed acute pyelonephritis.