Acyclovir(ゾビラックス)投与により重篤な中枢神経症状をみた腎不全患者の1例

概要

論文の詳細を見る
68歳男,血液透析患者。acyclovir投与により,中枢神経系の著明な副作用を経験した。すみやかな血液浄化療法による対処により短期間で症状を改善することができたA case of renal failure in a patient with severe central nervous system symptoms during oral acyclovir medication is reported. A 68-year-old man maintained on hemodialysis was given oral acyclovir 4,000 mg daily in divided doses because of herpes zoster affecting the left C3/5 dermatomes. He had vomiting and confusion 36 hours after administration. He had no focal neurological signs. The symptoms resolved 4 days after cessation of acyclovir administration and blood purification every day. Because of its high therapeutic index the use of acyclovir is associated with few side effects. In patients with renal failure the half-life of acyclovir is prolonged, this report indicates the importance of adhering to the dosage reductions in patients with renal failure.