Lomefloxacin 3日間連続投与後の前立腺組織内濃度について

概要

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LFLXは治療的に連続して投与された場合に,単回投与に比べて,血中および前立腺組織内の濃度が上昇しているため,これらの組織内に蓄積される傾向があると考えられた。LFLXの前立腺組織内濃度を測定した結果,グラム陽性菌の大部分の菌株のMICと,グラム陰性菌ほとんどすべてのMICを,200mg最終投与後約17時間の平均値でもかなり大幅に上回っていたThe penetration of Lomefloxacin (LFLX) into the prostatic tissue and the serum were examined. Forty four patients with benign prostatic hypertrophy treated with transurethral resection of the prostate (TUR-P) were entered in this study. LFLX was administered orally in a dose of 200 mg three times daily for three days preoperatively. The blood samples were taken simultaneously at the time of the tissue sampling. The patients were divided into groups 1 and 2. In group 1 (seventeen patients), the tissue sampling was done about 17 hours after the final drug administration. The mean concentration of LFLX was 3.31 +/- 1.16 micrograms/g in the prostatic tissue and 1.70 +/- 0.56 micrograms/ml in the serum. In group 2 (twenty seven patients), tissue sampling was done 5.5 hours after the final drug administration. The mean concentration of LFLX was 5.70 +/- 2.28 micrograms/g in the prostatic tissue and 2.93 +/- 1.14 micrograms/ml in the serum.