Sodium-4-〔2-{2,3-dimethyl-4-〔1-(4-isobutylphenyl)ethoxy〕benzoylamino}phenoxy〕butyrate (ONO-3805)のラット副***への効果

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新たに開発された非ステロイド系5α-reductase阻害剤,ONO-3805のラット副***への効果をchlormadione acetate (CMA)および非ステロイド系抗アンドロゲン剤flutamide (FLU)のそれと比較した.ONO-3805は副***重量低下についてCMAと同等の効果を示した.さらに,本剤は血清テストステロン・レベルに影響を与えることはなかったが,CMAおよびFLUはこれを有意に変動させたThe effects of sodium-4-[2-(2,3-dimethyl-4-[1-(4-isobutylphenyl) ethoxy]benzolamino)phenoxy]butyrate (ONO-3805), newly developed as a non-steroidal 5 alpha-reductase inhibitor, on rat accessory sex organs was compared with chlormadinone acetate (CMA) and non-steroidal antiandrogen, flutamide (FLU). ONO-3805 demonstrated excellent antiandrogenic activity which was similar to that of CMA in reducing the accessory sex organ weight. Moreover this agent did not show any significant effects on the serum testosterone level, but CMA and FLU changed it significantly. We previously reported the androgenic activity of antiandrogen (CMA, FLU, AA560, cyproterone acetate, medroxy progesterone, estrogen), but ONO-3805 is free of androgenic activity.