Stereologyによる膀胱癌の平均核容積の測定 - Point Sampled Interceptsによる測定 -

概要

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Stereologyの理論を応用した計測法を用いて,膀胱癌細胞の平均核容積を測定した.平均核容積は患者の予後と良好な相関を示したTo obtain objective information about bladder cancer, we measured the mean nuclear volume of bladder cancer cells by using the "Point Sampled Intercepts" method, which was published by Gundersen et al. Thirty one cases of bladder cancer were selected and divided into 2 groups: group A; no recurrence over 3 years after initial TUR (12 cases), group B; cystectomy or cancer death (19 cases). Estimated mean nuclear volume was significantly smaller in group A than in group B. It is suggested that estimation of the mean nuclear volume by this stereological method may provide objective information for predicting the prognosis of patients with bladder cancers. Further studies in additional patients are required to substantiate the predictive potential of this method.