腎癌肺転移にInterferon-α, 5-Fluorouracil,ロイコボリン併用療法を行った3例

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腎癌肺転移の3例(64歳男,66歳男,60歳男)に対し,BCMの概念に基づいたIFNα, 5-FU及びLVを用いた3剤併用療法を行った.1例でCR,2例でstable diseaseの結果をえた.主な副作用は口内炎,下痢であり,1例で5-FU投与を中止したが,2例では継続治療可能であったThree patients with lung metastases of renal cell carcinoma (RCC) were treated with a combination of interferon-alpha, leucovorin and 5-fluorouracil. All patients were male between 60 and 66 years and had been treated by nephrectomy prior to the combination therapy. Interferon-alpha was administered at the dose of 9 x 10(6) IU intramuscularly 3 times/week, leucovorin at 30 mg/m2 per day intravenously (day 1 to 5) and 5-fluorouracil at 500 mg/m2 daily by continuous infusion intravenously (day 1 to 5) followed by weekly bolus therapy. One patient achieved complete response for 17 months and the other two achieved stable disease for 6 and 16 months. Side effects related to this therapy were diarrhea, stomatitis, alopecia, leucocytopenia and thrombocytopenia. Grade 3 stomatitis occurred after the continuous administration of 5-fluorouracil in one patient; he recovered by discontinuation of 5-fluorouracil. Combination therapy with interferon-alpha, leucovolin and 5-fluorouracil might be effective for the treatment of lung metastases of RCC.