浸潤性膀胱癌に対する白金製剤を用いた化学放射線併用療法

概要

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根治的膀胱全摘除術や動注化学放射線療法が施行できない浸潤性膀胱癌に対して,白金製剤を用いた全身化学放射線併用療法を行い,8例中6例のCRが得られ,有害事象に関しても寛容であったEight patients with locally advanced bladder cancer who were not candidates for radical cystectomy or concurrent intra-arterial chemotherapy and radiotherapy were treated with combined platinum-based chemotherapy and radiation therapy. Six of the eight patients (75%) achieved a clinical complete response (CR). The effect of therapy in four patients whose histopathological responses were evaluated was effect grade 3. One of the eight patients died of treatment-related myelosuppression. The other two patients died of intercurrent disease, while the remaining five patients are alive with preservation of a functional bladder. The 2-year overall survival rate was 87.5%. Adverse events due to chemotherapy were mainly bone marrow suppression. Those caused by radiation therapy were rectal irritability. We considered concurrent platinum-based chemotherapy and radiotherapy useful for the treatment of locally advanced bladder cancer.