Iron Metabolism and Microtubules

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概要

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• Iron is required as a co-factor for a number of enzymes involved in fundamentalbiological processes such as respiration, photosynthesis and DNA synthesis. However, free iron is highly insoluble at physiological pH, and is incompatible with life because of inorganic reactions with oxygen that generate harmful oxy radicals. Thus, the bioavailability of iron in the physiological environment is maintained by a number of iron binding proteins in a highly regulated manner. Among the principal members of the iron homeostatic proteinsis ferritin, which is ubiquitously distributed in almost all living organisms ranging from unicellular bacteria to higher animals. As a multisubunit, nanocage protein with a mineral cavity for iron, ferritin safely stores iron in cells, preventing deleterious, abiotic reactions.Although ferritin has been extensively studied, and the mechanisms by which it assimilates and releases iron have been demonstrated, the cytoplasmic dynamics of ferritin and/or iron are still poorly understood. Recent studies have indicated the association of cytoplasmic ferritinwith the cytoskeletal network, in particular, with microtubules, which makes it probable that the regulation of the subcellular distribution and traffic of bio-iron is one of the important roles of microtubules, along with their well-known roles in cell morphology, cell division, and intracellular transport. This article first describes our general knowledge andunderstanding of iron metabolism, and later focuses on the recent progress and perspectives of the studies related to the cytoplasmic distribution and dynamics of ferritin in association with microtubules.

• 2009-06-30

著者

• Hasan Mohammad

  Department of Bioscience and Bioinformatics, Kyushu Institute of Technology

• Kotani Susumu

  Kanagawa Univ. Kanagawa Jpn

• Kotani S

  Kanagawa Univ. Kanagawa

• Kotani Susumu

  Department Of Biological Sciences Faculty Of Science Kanagawa University

• Nakagawa Hiroyuki

  Dept. of Biology, Fac. of Science, Univ of Fukuoka

関連論文

• Movement of Ferritin Oligomers in Hepatoma Cells
• Iron Metabolism and Microtubules
• Functional Analyses of a Neural Cell Specific Variant of Microtubule-Associated Protein 4
• An Alternatively Spliced Site in the Proline-Rich Region of Microtubule–Associated Protein 4 Plays an Important Role in Microtubule Stabilization
• An Isoform of Microtubule-associated Protein 4 Inhibits Kinesin-driven Microtubule Gliding
• 1P322 A microtubule-associated protein 4 specific five-repeat isoform inhibits kinesin-driven microtubule gliding(10. Cytoskeleton,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• 1P319 Differences in the regulation of microtubule stability by microtubule-associated protein 4 isoforms(10. Cytoskeleton,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• 1P317 The analysis of the binding between F-actin and Microtubule-associated protein 4 isoforms(10. Cytoskeleton,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• Identification of a Neural Cell Specific Variant of Microtubule-Associated Protein 4
• FUNCTION OF MICROTUBULE-ASSOCIATED PROTEIN 4 ISOFORMS, THE REPEAT REGION ORGANIZATIONS DIFFER FROM EACH OTHER(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• A UBIQUITOUSLY DISTRIBUTED MICROTUBULE-ASSOCIATED PROTEIN 4 (MAP4) EXPRESSES A NEURON-SPECIFIC ISOFORM(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• Functional Analysis of Microtubule-binding Domain of Bovine MAP4
• THE CHARACTERISTIC OF PERIODICAL DISTRIBUTION OF TECTAL OUTPUT NEURONS CONTROLLING PREY ORIENTING BEHAVIOR OF THE FROG(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• THE POSSIBLE FUNCTIONAL UNIT OF THE RETINOTECTAL MAP REVEALED BY DISTRIBUTION OF TECTAL OUTPUT NEURONS CONTROLLING PREY ORIENTING BEHAVIOR(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• 1P-194 二重蛍光蛋白質標識によるMAP4アイソフォームの細胞内局在観察(細胞生物学的課題(1),第46回日本生物物理学会年会)
• FUNCTIONAL ANALYSIS OF A NEURON-SPECIFIC MAP4 ISOFORM(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• ISOLATION AND CHARACTERIZATION OF MICROTUBULE-ASSOCIATED PROTEIN (MAP) 4 ISOFORMS THAT DIFFER IN THE AP SEQUENCE REPEATS(Biochemistry)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
• 1P321 Ferritin forms dynamic oligomers to associate with microtubules in vivo : Implication for the role of microtubules in iron metabolism(10. Cytoskeleton,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• 2D1624 NMRによるMAP4微小管結合部位断片の構造解析(蛋白質_構造機能相関1,第49回日本生物物理学会年会)
• Acute Toxicity and Neurobehavioral Effects of Diphenhydramine in Chicks
• Homogeneous Boiling Explosion during High Heat Flux Pulse Heating of Water
• The Smallest Active Fragment of Microtubule-Associated Protein 4 and Its Interaction with Microtubules in Phosphate Buffer

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