Movement of Ferritin Oligomers in Hepatoma Cells

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概要

• 論文の詳細を見る

• In mammalian cells, ferritin molecules form oligomers in response to the extracellulariron ion concentration. The distribution of oligomers is closely related to microtubules.However, it is still unclear how microtubules regulate the ferritin distribution in cytoplasm. To approach this question, we observed the movement of rhodamine conjugated　ferritin in HepG2 hepatoma cells using a live imaging technique. After a microinjection ofrhodamine-conjugated ferritin, rhodamine fluorescence was immediately incorporated into the oligomers. The trajectory of oligomer showed two different mode of movement: a fast-directional and a slow-random movement. Both movements were almost completely absent in cells treated with nocodazole, an anti-microtubule drug. These results indicate that ferritin oligomers are transported along microtubule in the cytoplasm by motor molecule(s).

• 2009-06-30

著者

• Hasan Mohammad

  Department of Bioscience and Bioinformatics, Kyushu Institute of Technology

関連論文

• Movement of Ferritin Oligomers in Hepatoma Cells
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