シナプス構築の形成機構 ─小脳プルキンエ細胞を中心に─

概要

論文の詳細を見る
Proper synaptic organization contributes crucial role in generating proper neuronal output. This article reviews a series of experiments aimed at investigating mechanism of formation of proper synaptic organization in cerebellar Purkinje cell (PC). Maturated PC receives two types of excitatory inputs, parallel fibers (PF) and climbing fiber, in segregated dendritic domain. During developing period, PF synapses induce elongation of PC dendrites and move to the elongated portion, and CF translocates along PC dendrite after PF synapses. PF and CF compete for spine to form synaptic contact and newly formed synapse is likely to be stabilized if it is to be proper. Furthermore, occupation of spines by PF synapses prevents from multiply CF innervation on PC dendrites. At adult, CF acts to maintain completed synaptic organization. In addition, the molecular that involve in the stabilization of excitatory synapses on PC have been reported.
札幌医科大学の論文
2008-12-01