A GENERAL METHOD FOR THE SYNTHESIS OF N-UNSUBSTITUTED 3,4-DIARYLPYRROLE-2,5-DICARBOXYLATES
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概要
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A general method for the synthesis of N-unsubstituted 3,4-diarylpyrrole-2,5-dicarboxylates (3) has been developed. The key reactions involved are the Hinsberg-type synthesis of dimethyl N-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate (6) followed by palladium-catalyzed Suzuki-Miyaura coupling of its bis-triflate derivative (7). The N-benzyl protecting group of the resulting 3,4-diarylpyrrole-2,5-dicarboxylates (8) is cleanly removed under hydrogenolytic or solvolytic conditions.
- Institute of Heterocyclic Chemistryの論文
- 2009-02-01
Institute of Heterocyclic Chemistry | 論文
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- A GENERAL METHOD FOR THE SYNTHESIS OF N-UNSUBSTITUTED 3,4-DIARYLPYRROLE-2,5-DICARBOXYLATES
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