Asymmetric Introduction of Nucleophiles to the 2-Position of Pyrrolidine Ring through N-Acylpyrrolidinium Ion

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概要

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• Asymmetric carbon-carbon bond-forming reaction at the 2-position of a pyrrolidine ring was achieved. The reaction involved a chiral Ti(IV) catalyzed coupling between 1-methoxycarboyl-2-methoxypyrrolidine and silyl enol ethers to afford 2-substituted pyrrolidines with up to 53 % ee.

• Institute of Heterocyclic Chemistryの論文
• 2005-12-31

著者

• Onomura Osamu

  Nagasaki Univ. Nagasaki Jpn

• Matsumura Yoshihiro

  Nagasaki Univ. Nagasaki Jpn

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• Memory of Chirality in the Electrochemical Oxidation of N-o-Phenylbenzoylated Prolinols
• Asymmetric Introduction of Nucleophiles to the 2-Position of Pyrrolidine Ring through N-Acylpyrrolidinium Ion

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