Synthesis of 1’,2’,3’,4’,5’-Pentamethyl-3,4-diphenylazaferrocene and Its Enantioselective C-2 Functionalization via (-)-Sparteine-Mediated Lithiation
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概要
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Lithiation of 1’,2’,3’,4’,5’-pentamethyl-3,4-diphenylazaferrocene (9) with sec-BuLi/(-)-sparteine (2) in Et2O at -78 °C followed by quenching with electrophiles gave the C-2 functionalized azaferrocenes (17) in good enantioselectivities (up to 79% ee). In contrast, treatment of 9 with tert-BuLi/(-)-sparteine (2) leaded to lateral lithiation at the methyl group of cyclopentadienyl ring.
- Institute of Heterocyclic Chemistryの論文
- 2008-11-01
Institute of Heterocyclic Chemistry | 論文
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