Effects of Ovarian Hormones on the Growth and the Differentiation of the Mouse Blastocyst During Delayed Implantation

概要

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Effects of progesterone and estradiol-17β on the growth and the differentiation of the mouse blastocyst during the pre-implantation and implantation stages was investigated inducing to delayed implantation by ovariectomy. When the ovariectomy was followed by daily injection of 1 mg progesterone (Group II), the area of blastocyst on the 6th day of pregnancy was significantly larger than that on the 4th day of pregnancy. When a single dose of estradiol-17β (0.5μg) was injected to ovariectomized and progesterone treated mice on the 4th or 6th day of pregnancy (Group III-A and III-B), the implantation was observed between 24 and 30 hrs. after the injection. In addition the area of blastocyst in Group III-A was significantly larger than that in Group II after 24 hrs. estradiol-17β injection and was as large as those in intact group (Group I) and Group II after 6 hrs. estradiol-1719 injection. The area of blastocyst in Group III-B was also significantly larger than that in Group II on and after 18 hrs. estradiol-17β injection. These results indicate that progesterone and estradiol-17β are important for the growth and the differentiation of delayed-implanting mouse blastocyst and they induce the implantation.
信州大学農学部の論文
1981-12-25