Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues
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概要
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Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.
- Cognizant Communication Corporationの論文
著者
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Tada Mitsuhiro
Division Of Cancer-related Genes Institute For Genetic Medicine Hokkaido University
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Hassan Nur
Geriatric Stomatology Department Of Oral Health Science Graduate School Of Dental Medicine Hokkaido
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Moriuchi Tetsuya
Hokkaido Urothelial Cancer Research Group
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Moriuchi Tetsuya
Department Of Cell Biology Tokai University School Of Medicine
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Moriuchi Tetsuya
Division Of Cancer-related Genes Institute For Genetic Medicine Hokkaido University
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Inoue Nobuo
Geriatric Stomatology Department Of Oral Health Science Graduate School Of Dental Medicine Hokkaido
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Kashiwazaki Haruhiko
Geriatric Stomatology Department Of Oral Health Science Graduate School Of Dental Medicine Hokkaido
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