Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
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概要
- 論文の詳細を見る
There have been several researches on the role of personality in the pathophysiology of bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Therefore, in this study, we examined the relationship between the XBP1 gene polymorphism and the personality traits assessed by two self-rating scales, a shortened version of Temperament and Character Inventory (TCI) and NEO-Five Factor Inventory (NEO-FFI) in healthy subjects. The present results suggested that the XBP1 gene polymorphism was associated with the NEO-FFI score of neuroticism in female subjects. However, no significant differences in the other personality scale scores of both assessments were observed among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments.
- 2005-12-31
著者
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Kato Tadafumi
The Institute Of Physical And Chemical Research Riken
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Kato Chieko
Department Of Neuropsychiatry Graduate School Of Medicine University Of Tokyo
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Kakiuchi Chihiro
理化学研究所脳科学総合研究センター 精神疾患動態研究チーム
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Kakiuchi Chihiro
Laboratory For Molecular Dynamics Of Mental Disorders Riken Brain Science Institute
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Kunugi Hiroshi
Department Of Mental Disorder Research National Institute Of Neuroscience National Center Of Neurolo
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Kunugi Hiroshi
Dep. Of Mental Disorder Res. National Inst. Of Neuroscience National Center Of Neurology And Psychia
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