Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
スポンサーリンク
概要
- 論文の詳細を見る
Dysregulations of calcium (Ca) homeostasis may be involved in the pathophysiology of bipolar disorder. Enhanced Ca response to various agonists in peripheral blood cells is one of a few confirmed biological markers for bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Thus, in this study, we examined the relationship between the XBP1 gene polymorphism and the Ca signaling in the platelets of healthy controls. The present results suggest no significant difference in the basal Ca level or 5-HT-induced Ca mobilization among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder.http://www.sciencedirect.com/science/journal/03043940
- Elsevierの論文
- 2004-10-07
著者
-
Kato Tadafumi
The Institute Of Physical And Chemical Research Riken
-
Kato Chieko
Department Of Neuropsychiatry Graduate School Of Medicine University Of Tokyo
-
Kakiuchi Chihiro
理化学研究所脳科学総合研究センター 精神疾患動態研究チーム
-
Kakiuchi Chihiro
Laboratory For Molecular Dynamics Of Mental Disorders Riken Brain Science Institute
-
Kunugi Hiroshi
Department Of Mental Disorder Research National Institute Of Neuroscience National Center Of Neurolo
-
Kunugi Hiroshi
Dep. Of Mental Disorder Res. National Inst. Of Neuroscience National Center Of Neurology And Psychia
関連論文
- Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
- No evidence for significant association between GABA receptor genes in chromosome 15q11-q13 and autism in a Japanese population
- No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population
- Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism
- Association analysis of HSP90B1 with bipolar disorder
- Serum cholesterol, uric acid and cholinesterase in victims of the Tokyo subway sarin poisoning : A relation with post-traumatic stress disorder
- Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population
- Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes
- Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
- Support for relationship between serum cholinesterase and post-traumatic stress disorder ; 5-year follow-ups of victims of the Tokyo subway sarin poisoning
- Post-traumatic stress disorder symptoms in victims of Tokyo subway attack : a 5-year follow-up study
- Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
- Altered RNA editing of serotonin 2C receptor in a rat model of depression
- Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
- Molecular genetic studies of schizophrenia : challenges and insights
- Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population
- Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics
- A genome-wide CNV association study on panic disorder in a Japanese population
- Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder
- A 3-bp deletion of mitochondrial DNA tRNA^ observed in lymphoblastoid cells
- An association study between the dymeclin gene and schizophrenia in the Japanese population
- A two-stage case-control association study of PADI2 with schizophrenia
- Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia
- Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population