Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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概要

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• Vanillin and furfural are derived from lignocellulosic biomass and inhibit yeast growth and fermentation as biomass conversion inhibitors. Furfural has been shown to induce oxidative stress in Saccharomyces cerevisiae. Since there has been no report on the relationship between vanillin and oxidative stress, we investigated whether vanillin caused oxidative stress in yeast cells. We showed that vanillin caused the nuclear accumulation of Yap1, an oxidative stress responsive transcription factor, and subsequent transcriptional activation of Yap1-target genes. The growth of the null mutant of the YAP1 gene (yap1Δ) was delayed in the presence of vanillin, which indicated that Yap1 plays a role in the acquisition of tolerance to vanillin. We also demonstrated that vanillin facilitated the fragmentation of mitochondna. These findings suggest that the toxicity of vanillin involves damage induced by oxidative stress.

• 公益社団法人日本生物工学会の論文

著者

• Izawa Shingo

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Ohya Yoshikazu

  Department Of Biological Sciences Graduate School Of Science University Of To

• OHYA Yoshikazu

  Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo

• Nguyen Trinh

  Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology

• Iwaki Aya

  Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology

• Izawa Shingo

  Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology

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• Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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