J052022 集束超音波によるソナゾイドの破壊と気泡生成([J05201]ドラッグデリバリーシステムでの流動現象とデバイス開発(2))

概要

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Sonazoid microbubbles have been destroyed by the irradiation of a 1 MHz ultrasound (US). Both burst waves and continuous waves of US were radiated by means of a concave ultrasound probe with the arithmetic focal length of 80 mm. A suspension of Sonazoid ultrasound contrast agent with the volumetric concentration of C. was poured into a cuvette which was positioned with its bottom in contact with the free surface and exposed to US with the duration of T. After the interaction between a suspension and an ultrasound, Sonazoid microbubbles were quickly destroyed. The survival number of Sonazoid microbubbles has been examined by changing the exposure time T・, the concentration of a suspension Cs and the duty ratio D. Sonazoid destruction yields several pieces of debris together with gas flowing out which act as nuclei of bubble growth. Snapshots of bubbles were taken by using a Xe flash with the pulse duration of 2 ps as a light source.
2011-09-11