同種末梢血幹細胞採取におけるドナーアフェレシスの安全管理 : 日本造血細胞移植学会・日本輸血学会のガイドラインから(<特集>ドナーアフェレシスの安全性)

概要

論文の詳細を見る
Besides bone marrow cells, peripheral blood stem cells(PBSC)have been used as an alternative cell source for allogeneic hematopoietic stem cell transplantation. PBSC are mobilized with high-dose granulocyte colony-stimulating factor and collected by large-volume aphereses. Bone pain, general fatigue, headache, fever, and an increase in ALP, LDH, CRP, and platelet aggregation have been reported as short-term adverse effects of G-CSF, and serious rare complications, including myocardial infarction, cerebrovascular accidents, and rupture of the spleen, are known. The long-term adverse effects of G-CSF are undefined. Large-volume aphereses are also known to be associated with potentially fatal complications such as citrate-induced hypocalcemia, vasovagal reflex, thrombocytopenia, and capillary leak syndrome. The Japan Society for Hematopoietic Cell Transplantation established the Donor Registry to study the short- and long- term effects of G-CSF administration and aphereses in April 2000. The Combined Committee of the Japan Society for Hematopoietic Cell Transplantation and the Japan Society of Blood Transfusion issued guidelines on the mobilization and collection of PBSC from healthy donors for allogeneic PBSC transplantation. It is essential that the guidelines be observed and that all the donors be registered to secure safety and to understand the effects of the procedures on healthy volunteer donors.
2002-10-31